John N Mariani
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Explore the profile of John N Mariani including associated specialties, affiliations and a list of published articles.
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20
Citations
872
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Recent Articles
11.
Dutta D, Zameer A, Mariani J, Zhang J, Asp L, Huynh J, et al.
Development
. 2018 Jul;
145(13).
PMID: 30006479
No abstract available.
12.
Horng S, Therattil A, Moyon S, Gordon A, Kim K, Argaw A, et al.
J Clin Invest
. 2017 Jul;
127(8):3136-3151.
PMID: 28737509
Lesions and neurologic disability in inflammatory CNS diseases such as multiple sclerosis (MS) result from the translocation of leukocytes and humoral factors from the vasculature, first across the endothelial blood-brain...
13.
Laitman B, Mariani J, Zhang C, Sawai S, John G
PLoS One
. 2017 Jan;
12(1):e0170477.
PMID: 28107514
Proper regulation of the coordinated transcriptional program that drives oligodendrocyte (OL) differentiation is essential for central nervous system myelin formation and repair. Nuclear import, mediated in part by a group...
14.
Laitman B, Asp L, Mariani J, Zhang J, Liu J, Sawai S, et al.
PLoS Biol
. 2016 May;
14(5):e1002467.
PMID: 27213272
Growth factors of the gp130 family promote oligodendrocyte differentiation, and viability, and myelination, but their mechanisms of action are incompletely understood. Here, we show that these effects are coordinated, in...
15.
Chapouly C, Yao Q, Vandierdonck S, Larrieu-Lahargue F, Mariani J, Gadeau A, et al.
Cardiovasc Res
. 2015 Dec;
109(2):217-27.
PMID: 26645982
Aims: Microangiopathy, i.e. endothelial dysfunction, has long been suggested to contribute to the development of diabetic neuropathy, although this has never been fully verified. In the present paper, we have...
16.
Chapouly C, Argaw A, Horng S, Castro K, Zhang J, Asp L, et al.
Brain
. 2015 Mar;
138(Pt 6):1548-67.
PMID: 25805644
In inflammatory central nervous system conditions such as multiple sclerosis, breakdown of the blood-brain barrier is a key event in lesion pathogenesis, predisposing to oedema, excitotoxicity, and ingress of plasma...
17.
Dutta D, Zameer A, Mariani J, Zhang J, Asp L, Huynh J, et al.
Development
. 2014 Jun;
141(12):2414-28.
PMID: 24917498
In the embryonic CNS, development of myelin-forming oligodendrocytes is limited by bone morphogenetic proteins, which constitute one arm of the transforming growth factor-β (Tgfβ) family and signal canonically via Smads...
18.
Argaw A, Asp L, Zhang J, Navrazhina K, Pham T, Mariani J, et al.
J Clin Invest
. 2012 Jun;
122(7):2454-68.
PMID: 22653056
In inflammatory CNS conditions such as multiple sclerosis (MS), current options to treat clinical relapse are limited, and more selective agents are needed. Disruption of the blood-brain barrier (BBB) is...
19.
Zhang J, Kramer E, Asp L, Dutta D, Navrazhina K, Pham T, et al.
FEBS Lett
. 2011 Aug;
585(23):3813-20.
PMID: 21864535
Multiple sclerosis (MS) is an inflammatory demyelinating disease of the CNS. Conduction block in demyelinated axons underlies early neurological symptoms, but axonal transection and neuronal loss are believed to be...
20.
Moore E, Mariani J, Linsenbardt D, Melon L, Boehm 2nd S
Alcohol Clin Exp Res
. 2010 Jan;
34(4):734-42.
PMID: 20102570
Background: Alcohol use is common during the adolescent period, a time at which a number of crucial neurobiological, hormonal, and behavioral changes occur (Spear, 2000). In order to more fully...