John Leszyk
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Explore the profile of John Leszyk including associated specialties, affiliations and a list of published articles.
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31
Citations
2352
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Recent Articles
1.
DeSimone A, Leszyk J, Wagner K, Emerson Jr C
Sci Adv
. 2019 Dec;
5(12):eaaw7099.
PMID: 31844661
Facioscapulohumeral muscular dystrophy (FSHD) is linked to epigenetic derepression of the germline/embryonic transcription factor DUX4 in skeletal muscle. However, the etiology of muscle pathology is not fully understood, as DUX4...
2.
Haraszti R, Miller R, Dubuke M, Rockwell H, Coles A, Sapp E, et al.
iScience
. 2019 Jun;
16:230-241.
PMID: 31195240
Exosomes can serve as delivery vehicles for advanced therapeutics. The components necessary and sufficient to support exosomal delivery have not been established. Here we connect biochemical composition and activity of...
3.
Ganesan R, Leszyk J, Jacobson A
Methods
. 2018 Dec;
155:58-67.
PMID: 30593864
Ribosomes associated with nonsense-mediated decay factors Upf1, Upf2, or Upf3 were purified by immunoprecipitation, and enrichment and stoichiometry of Upf factors and ribosomal proteins were analyzed by western blot and...
4.
Maziuk B, Apicco D, Cruz A, Jiang L, Ash P, Lummertz da Rocha E, et al.
Acta Neuropathol Commun
. 2018 Aug;
6(1):71.
PMID: 30068389
The development of insoluble, intracellular neurofibrillary tangles composed of the microtubule-associated protein tau is a defining feature of tauopathies, including Alzheimer's disease (AD). Accumulating evidence suggests that tau pathology co-localizes...
5.
Gao X, Tu L, Mir A, Rodriguez T, Ding Y, Leszyk J, et al.
Nat Methods
. 2018 May;
15(6):433-436.
PMID: 29735996
Mapping proteomic composition at distinct genomic loci in living cells has been a long-standing challenge. Here we report that dCas9-APEX2 biotinylation at genomic elements by restricted spatial tagging (C-BERST) allows...
6.
Sakatos A, Babunovic G, Chase M, Dills A, Leszyk J, Rosebrock T, et al.
Sci Adv
. 2018 May;
4(5):eaao1478.
PMID: 29732401
There is increasing evidence that phenotypically drug-resistant bacteria may be important determinants of antibiotic treatment failure. Using high-throughput imaging, we defined distinct subpopulations of mycobacterial cells that exhibit heritable but...
7.
Cormier N, McGlone J, Leszyk J, Hardy D
PLoS One
. 2018 Jan;
13(1):e0190891.
PMID: 29342175
Sperm competence in animal fertilization requires the collective activities of numerous sperm-specific proteins that are typically alloimmunogenic in females. Consequently, sperm membrane alloantigens are potential targets for contraceptives that act...
8.
Apicco D, Ash P, Maziuk B, LeBlang C, Medalla M, Al Abdullatif A, et al.
Nat Neurosci
. 2017 Dec;
21(1):72-80.
PMID: 29273772
Emerging studies suggest a role for tau in regulating the biology of RNA binding proteins (RBPs). We now show that reducing the RBP T-cell intracellular antigen 1 (TIA1) in vivo...
9.
Prokaeva T, Akar H, Spencer B, Havasi A, Cui H, OHara C, et al.
Kidney Int Rep
. 2017 Dec;
2(6):1223-1232.
PMID: 29270531
No abstract available.
10.
Chen L, Paquette N, Mamoor S, Rus F, Nandy A, Leszyk J, et al.
J Biol Chem
. 2017 Apr;
292(21):8738-8749.
PMID: 28377500
Coordinated regulation of innate immune responses is necessary in all metazoans. In the Imd pathway detects Gram-negative bacterial infections through recognition of diaminopimelic acid (DAP)-type peptidoglycan and activation of the...