John J Reiners Jr
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Explore the profile of John J Reiners Jr including associated specialties, affiliations and a list of published articles.
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42
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2627
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Recent Articles
21.
Elliott A, Reiners Jr J
Toxicol Appl Pharmacol
. 2008 Jul;
232(2):169-79.
PMID: 18655802
p-Anilinoaniline (pAA) is an aromatic amine that is widely used in hair dying applications. It is also a metabolite of metanil yellow, an azo dye that is commonly used as...
22.
Kessel D, Price M, Reiners Jr J
Photochem Photobiol
. 2008 Jun;
84(5):1272-6.
PMID: 18513234
The proapoptotic effects of the Bcl-2 antagonist HA14-1 are believed to derive from its affinity for the hydrophobic groove on Bcl-2 and Bcl-x(L), thereby displacing proapoptotic factors, e.g. Bax and...
23.
Wojtkowiak J, Fouad F, Lalonde D, Kleinman M, Gibbs R, Reiners Jr J, et al.
J Pharmacol Exp Ther
. 2008 Mar;
326(1):1-11.
PMID: 18367665
Neurofibromatosis type 1 (NF1) is a genetic disorder that is driven by the loss of neurofibromin (Nf) protein function. Nf contains a Ras-GTPase-activating protein domain, which directly regulates Ras signaling....
24.
Kessel D, Reiners Jr J
Photochem Photobiol
. 2007 Sep;
83(5):1024-8.
PMID: 17880495
Photodynamic therapy (PDT) can cause lethal photodamage by both direct and indirect mechanisms. Direct modes of cell death relate to nonspecific necrosis and the initiation of signaling pathways that elicit...
25.
Clark M, Scott S, Wojtkowiak J, Chirco R, Mathieu P, Reiners Jr J, et al.
J Med Chem
. 2007 Jun;
50(14):3274-82.
PMID: 17555307
Certain farnesyl diphosphate (FPP) analogs are potent inhibitors of the potential anticancer drug target protein farnesyltransferase (FTase), but these compounds are not suitable as drug candidates. Thus, phosphoramidate prodrug derivatives...
26.
Kessel D, Reiners Jr J, Hazeldine S, Polin L, Horwitz J
Mol Cancer Ther
. 2007 Jan;
6(1):370-9.
PMID: 17237296
The phenoxypropionic acid derivative 2-{4-[(7-chloro-2-quinoxalinyl)oxy]phenoxy}propionic acid (XK469) and an analogue termed 2-{4-[(7-bromo-2-quinalinyl)oxy]phenoxy}propionic acid (SH80) can eradicate malignant cell types resistant to many common antitumor agents. Colony formation assays indicated that...
27.
Kessel D, Reiners Jr J
Cancer Lett
. 2006 Oct;
249(2):294-9.
PMID: 17055152
L1210 murine leukemia cells exposed to an LD(90) concentration of the Bcl-2/Bcl-x(L) antagonist HA14-1 rapidly undergo apoptosis but also develop numerous intracellular vacuoles with double membranes, exhibit enhanced labeling by...
28.
Caruso J, Reiners Jr J
Apoptosis
. 2006 Oct;
11(11):1877-85.
PMID: 17013759
BID is an essential component of many apoptotic pathways. Cytosolic proteases cleave BID within an extended loop region, generating an active truncated fragment which synergizes with BAX and BAK to...
29.
Kessel D, Vicente M, Reiners Jr J
Autophagy
. 2006 Aug;
2(4):289-90.
PMID: 16921269
This study was designed to examine modes of cell death after photodynamic therapy (PDT). Murine leukemia L1210 cells and human prostate Bax-deficient DU-145 cells were examined after PDT-induced photodamage to...
30.
Dilworth J, Kraniak J, Wojtkowiak J, Gibbs R, Borch R, Tainsky M, et al.
Biochem Pharmacol
. 2006 Jun;
72(11):1485-92.
PMID: 16797490
Neurofibromatosis type 1 (NF1) is the most common cancer predisposition syndrome. NF1 patients present with a constellation of clinical manifestations and have an increased risk of developing certain benign and...