John J Reiners Jr
Overview
Explore the profile of John J Reiners Jr including associated specialties, affiliations and a list of published articles.
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42
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2627
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Recent Articles
11.
Klionsky D, Abdalla F, Abeliovich H, Abraham R, Acevedo-Arozena A, Adeli K, et al.
Autophagy
. 2012 Sep;
8(4):445-544.
PMID: 22966490
In 2008 we published the first set of guidelines for standardizing research in autophagy. Since then, research on this topic has continued to accelerate, and many new scientists have entered...
12.
Kessel D, Price M, Reiners Jr J
Autophagy
. 2012 Aug;
8(9):1333-41.
PMID: 22889762
Photodynamic therapy (PDT) involves photosensitizing agents that, in the presence of oxygen and light, initiate formation of cytotoxic reactive oxygen species (ROS). PDT commonly induces both apoptosis and autophagy. Previous...
13.
Elliott A, Joiakim A, Mathieu P, Duniec-Dmuchowski Z, Kocarek T, Reiners Jr J
Drug Metab Dispos
. 2012 Feb;
40(5):1032-40.
PMID: 22344700
The aryl hydrocarbon receptor (AhR) is targeted by ubiquitination for degradation by the proteasome shortly after its activation by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). In silico screening identified p-anilinoaniline (pAA) as a putative...
14.
Wojtkowiak J, Sane K, Kleinman M, Sloane B, Reiners Jr J, Mattingly R
J Pharmacol Exp Ther
. 2011 Jan;
337(1):65-74.
PMID: 21228063
Exposure of the human malignant peripheral nerve sheath tumor cell lines STS-26T, ST88-14, and NF90-8 to nanomolar concentrations of both lovastatin and farnesyl transferase inhibitor (FTI)-1 but not to either...
15.
Reiners Jr J, Kleinman M, Kessel D, Mathieu P, Caruso J
Free Radic Biol Med
. 2010 Nov;
50(2):281-94.
PMID: 21074609
Reactive oxygen species (ROS) can induce lysosomal membrane permeabilization (LMP). Photoirradiation of murine hepatoma 1c1c7 cultures preloaded with the photosensitizer NPe6 generates singlet oxygen within acidic organelles and causes LMP...
16.
Kraniak J, Sun D, Mattingly R, Reiners Jr J, Tainsky M
Mol Cell Biochem
. 2010 Aug;
344(1-2):267-76.
PMID: 20680410
Plexiform neurofibromas commonly found in patients with Neurofibromatosis type I (NF1) have a 5% risk of being transformed into malignant peripheral nerve sheath tumors (MPNST). Germline mutations in the NF1...
17.
Sane K, Mynderse M, Lalonde D, Dean I, Wojtkowiak J, Fouad F, et al.
J Pharmacol Exp Ther
. 2010 Jan;
333(1):23-33.
PMID: 20086055
Prenylation inhibitors have gained increasing attention as potential therapeutics for cancer. Initial work focused on inhibitors of farnesylation, but more recently geranylgeranyl transferase inhibitors (GGTIs) have begun to be evaluated...
18.
Reiners Jr J, Agostinis P, Berg K, Oleinick N, Kessel D
Autophagy
. 2009 Oct;
6(1):7-18.
PMID: 19855190
Photodynamic therapy (PDT) is a procedure that has applications in the selective eradication of neoplasia where sites of malignant lesions are clearly delineated. It is a two-step process whereby cells...
19.
Reiners Jr J, Kleinman M, Joiakim A, Mathieu P
J Pharmacol Exp Ther
. 2008 Dec;
328(3):796-806.
PMID: 19066341
The therapeutic usefulness of the quinoxaline derivatives XK469 (2-{4-[(7-chloro-2-quinoxalinyl)oxy]phenoxy}propionic acid) and SH80 (2-{4-[(7-bromo-2-quinolinyl)oxy]phenoxy}propionic acid) has been attributed to their abilities to induce G(2)/M arrest and apoptotic or autophagic cell death....
20.
Dilworth J, Wojtkowiak J, Mathieu P, Tainsky M, Reiners Jr J, Mattingly R, et al.
Cancer Biol Ther
. 2008 Oct;
7(12):1938-46.
PMID: 18927496
Neurofibromatosis Type 1 (NF1) is characterized by the abnormal proliferation of neuroectodermal tissues and the development of certain tumors, particularly neurofibromas, which may progress into malignant peripheral nerve sheath tumors...