John E Allen
Overview
Explore the profile of John E Allen including associated specialties, affiliations and a list of published articles.
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Articles
9
Citations
338
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Recent Articles
1.
Hass H, Masson K, Wohlgemuth S, Paragas V, Allen J, Sevecka M, et al.
NPJ Syst Biol Appl
. 2017 Sep;
3:27.
PMID: 28944080
Targeted therapies have shown significant patient benefit in about 5-10% of solid tumors that are addicted to a single oncogene. Here, we explore the idea of ligand addiction as a...
2.
Yi C, Allen J, Russo B, Lee S, Heindl J, Baxt L, et al.
J Biol Chem
. 2014 Aug;
289(43):30101-13.
PMID: 25124035
Diseases caused by many Gram-negative bacterial pathogens depend on the activities of bacterial effector proteins that are delivered into eukaryotic cells via specialized secretion systems. Effector protein function largely depends...
3.
Bacharis M, Coppins M, Allen J
Phys Rev E Stat Nonlin Soft Matter Phys
. 2010 Sep;
82(2 Pt 2):026403.
PMID: 20866922
Dust produced in tokamaks is an important issue for fusion. Dust particles can introduce health and safety issues when in the same time can have an impact on reactor performance....
4.
Kaushansky A, Allen J, Gordus A, Stiffler M, Karp E, Chang B, et al.
Nat Protoc
. 2010 Apr;
5(4):773-90.
PMID: 20360771
Protein microarrays provide an efficient way to identify and quantify protein-protein interactions in high throughput. One drawback of this technique is that proteins show a broad range of physicochemical properties...
5.
Chen J, Chang B, Allen J, Stiffler M, MacBeath G
Nat Biotechnol
. 2008 Aug;
26(9):1041-5.
PMID: 18711339
PDZ domains constitute one of the largest families of interaction domains and function by binding the C termini of their target proteins. Using Bayesian estimation, we constructed a three-dimensional extension...
6.
Splan K, Allen J, McLendon G
Biochemistry
. 2007 Oct;
46(42):11938-44.
PMID: 17910418
XIAP (X-linked inhibitor of apoptosis protein) is involved in the mediation of programmed cell death and, therefore, is a target for the development of cancer therapeutics. Peptide mimetics based upon...
7.
Stiffler M, Chen J, Grantcharova V, Lei Y, Fuchs D, Allen J, et al.
Science
. 2007 Jul;
317(5836):364-9.
PMID: 17641200
PDZ domains have long been thought to cluster into discrete functional classes defined by their peptide-binding preferences. We used protein microarrays and quantitative fluorescence polarization to characterize the binding selectivity...
8.
Mettu N, Stanley T, Dwyer M, Jansen M, Allen J, Hall J, et al.
Mol Endocrinol
. 2007 Jun;
21(10):2361-77.
PMID: 17595321
The peroxisome proliferator-activated receptors (PPARalpha, PPARdelta, and PPARgamma) constitute a family of nuclear receptors that regulates metabolic processes involved in lipid and glucose homeostasis. Although generally considered to function as...
9.
Allen J, McLendon G
Biochem Biophys Res Commun
. 2006 Sep;
349(4):1264-8.
PMID: 16979582
Fluorescent lanthanide ions, with large Stokes shifts and narrow emission bands, are excellent tools for the development of FRET-based assays. In this work, a terbium ion is tethered to a...