George L McLendon
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Explore the profile of George L McLendon including associated specialties, affiliations and a list of published articles.
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Articles
18
Citations
175
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Recent Articles
1.
Chakrabarti R, Rabitz H, Springs S, McLendon G
Phys Rev Lett
. 2008 Jul;
100(25):258103.
PMID: 18643707
Elucidating the fitness measures optimized during the evolution of complex biological systems is a major challenge in evolutionary theory. We present experimental evidence and an analytical framework demonstrating how biochemical...
2.
Splan K, Allen J, McLendon G
Biochemistry
. 2007 Oct;
46(42):11938-44.
PMID: 17910418
XIAP (X-linked inhibitor of apoptosis protein) is involved in the mediation of programmed cell death and, therefore, is a target for the development of cancer therapeutics. Peptide mimetics based upon...
3.
Wist A, Gu L, Riedl S, Shi Y, McLendon G
Bioorg Med Chem
. 2007 Mar;
15(8):2935-43.
PMID: 17336535
A small series of peptide mimics was designed and synthesized to contain a heterocyclic ring in place of the potentially labile N-terminal peptide bond of the tetrapeptide containing the Smac-XIAP-binding...
4.
Allen J, McLendon G
Biochem Biophys Res Commun
. 2006 Sep;
349(4):1264-8.
PMID: 16979582
Fluorescent lanthanide ions, with large Stokes shifts and narrow emission bands, are excellent tools for the development of FRET-based assays. In this work, a terbium ion is tethered to a...
5.
Tan W, Cheng W, Webber A, Bhambhani A, Duff M, Kumar C, et al.
J Biol Inorg Chem
. 2005 Oct;
10(7):790-9.
PMID: 16208493
Heme proteins, metmyoglobin, methemoglobin, and metcytochrome c showed unusual affinity for double-stranded DNA. Calorimetric studies show that binding of methemoglobin to calf thymus DNA (CTDNA) is weakly endothermic, and the...
6.
Doerr A, McLendon G
Inorg Chem
. 2004 Dec;
43(25):7916-25.
PMID: 15578825
Metal ions serve many purposes in natural proteins, from the stabilization of tertiary structure to the direction of protein folding to crucial roles in electron transfer and catalysis. There is...
7.
Case M, McLendon G
Acc Chem Res
. 2004 Oct;
37(10):754-62.
PMID: 15491122
Metal-assembled parallel helix-bundle proteins have been used to investigate electron transfer through alpha-helical structures. Fermi Golden Rule distance dependence of electron transfer rates was established in a family of designed...
8.
Balakrishnan G, Tsai C, Wu Q, Case M, Pevsner A, McLendon G, et al.
J Mol Biol
. 2004 Jun;
340(4):857-68.
PMID: 15223326
The dynamical effect of eliminating specific tertiary H-bonds in the hemoglobin (Hb) tetramer has been investigated by site-directed mutagenesis and time-resolved absorption and ultraviolet resonance Raman (UVRR) spectroscopy. The Trp...
9.
Balakrishnan G, Case M, Pevsner A, Zhao X, Tengroth C, McLendon G, et al.
J Mol Biol
. 2004 Jun;
340(4):843-56.
PMID: 15223325
Hemoglobin undergoes a series of molecular changes on the nanosecond and microsecond time-scale following photodissociation of CO ligands. We have monitored these processes with a combination of transient absorption and...
10.
Doerr A, Case M, Pelczer I, McLendon G
J Am Chem Soc
. 2004 Apr;
126(13):4192-8.
PMID: 15053608
A metal-assembled homotrimeric coiled coil based on the GCN4-p1 sequence has been designed that noncovalently binds hexafluorobenzene and other similar ligands in a hydrophobic cavity, created by making the core...