John Allocco
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Explore the profile of John Allocco including associated specialties, affiliations and a list of published articles.
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10
Citations
512
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Recent Articles
1.
Tannu S, Allocco J, Yarde M, Wong P, Ma X
J Pharmacol Toxicol Methods
. 2020 Oct;
106:106935.
PMID: 33096237
Introduction: Murine transverse aortic constriction (TAC) is a frequently used model of pressure overload-induced left ventricular (LV) remodeling. However, there is considerable variability in disease progression to overt heart failure...
2.
Ma X, Tannu S, Allocco J, Pan J, Dipiero J, Wong P
J Pharmacol Toxicol Methods
. 2019 Feb;
96:78-86.
PMID: 30738210
Introduction: Mouse models of chronic heart failure (HF) have been widely used in HF research. However, the current HF models most often use the C57BL/6 mouse strain and do not...
3.
Singh S, Goetz M, Smith S, Zink D, Polishook J, Onishi R, et al.
Bioorg Med Chem Lett
. 2012 Oct;
22(23):7127-30.
PMID: 23084277
Emergence of bacterial resistance has eroded the effectiveness of many life saving antibiotics leading to an urgent need for new chemical classes of antibacterial agents. We have applied a Staphylococcus...
4.
Powles M, Allocco J, Yeung L, Nare B, Liberator P, Schmatz D
Antimicrob Agents Chemother
. 2012 Feb;
56(5):2414-9.
PMID: 22314528
Malaria continues to have a significant impact on the health of the developing world. Efforts to combat this disease now focus on combination therapy in order to stem the emergence...
5.
Phillips J, Goetz M, Smith S, Zink D, Polishook J, Onishi R, et al.
Chem Biol
. 2011 Aug;
18(8):955-65.
PMID: 21867911
Bacterial resistance to known therapeutics has led to an urgent need for new chemical classes of antibacterial agents. To address this we have applied a Staphylococcus aureus fitness test strategy...
6.
Jiang B, Xu D, Allocco J, Parish C, Davison J, Veillette K, et al.
Chem Biol
. 2008 Apr;
15(4):363-74.
PMID: 18420143
Natural products provide an unparalleled source of chemical scaffolds with diverse biological activities and have profoundly impacted antimicrobial drug discovery. To further explore the full potential of their chemical diversity,...
7.
Donald R, Zhong T, Wiersma H, Nare B, Yao D, Lee A, et al.
Mol Biochem Parasitol
. 2006 Jun;
149(1):86-98.
PMID: 16765465
Trisubstituted pyrrole inhibitors of the essential coccidian parasite cGMP dependent protein kinase (PKG) block parasite invasion and show in vivo efficacy against Eimeria in chickens and Toxoplasma in mice. An...
8.
Wang J, Soisson S, Young K, Shoop W, Kodali S, Galgoci A, et al.
Nature
. 2006 May;
441(7091):358-61.
PMID: 16710421
Bacterial infection remains a serious threat to human lives because of emerging resistance to existing antibiotics. Although the scientific community has avidly pursued the discovery of new antibiotics that interact...
9.
Diaz C, Allocco J, Powles M, Yeung L, Donald R, Anderson J, et al.
Mol Biochem Parasitol
. 2005 Dec;
146(1):78-88.
PMID: 16325279
Cyclic GMP-dependent protein kinase (PKG) has been biochemically and genetically validated in Toxoplasma gondii as a primary target responsible for the antiparasitic activity of the trisubstituted pyrrole 4-[2-(4-fluorophenyl)-5-(1-methylpiperidine-4-yl)-1H pyrrol-3-yl] pyridine...
10.
Donald R, Allocco J, Singh S, Nare B, Salowe S, Wiltsie J, et al.
Eukaryot Cell
. 2002 Nov;
1(3):317-28.
PMID: 12455981
The trisubstituted pyrrole 4-[2-(4-fluorophenyl)-5-(1-methylpiperidine-4-yl)-1H-pyrrol-3-yl]pyridine (compound 1) has in vivo activity against the apicomplexan parasites Toxoplasma gondii and Eimeria tenella in animal models. The presumptive molecular target of this compound in...