John-Paul Denson
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Explore the profile of John-Paul Denson including associated specialties, affiliations and a list of published articles.
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Articles
18
Citations
540
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Recent Articles
1.
Hanson Q, Hu X, Pal S, Recabo K, Ye L, Poon I, et al.
Biochemistry
. 2025 Jan;
64(2):419-431.
PMID: 39789725
SARS-CoV-2 infections led to a worldwide pandemic in 2020. As of 2024, therapeutics against SARS-CoV-2 have continued to be desirable. NSP14 is a dual-function methyltransferase (MTase) and exonuclease (ExoN) with...
2.
Maciag A, Stice J, Wang B, Sharma A, Chan A, Lin K, et al.
Cancer Discov
. 2024 Dec;
15(3):578-594.
PMID: 39642212
Approved inhibitors of KRASG12C prevent oncogenic activation by sequestering the inactive, GDP-bound (OFF) form rather than directly binding and inhibiting the active, GTP-bound (ON) form. This approach provides no direct...
3.
Messing S, Widmeyer S, Denson J, Mehalko J, Wall V, Drew M, et al.
Protein Expr Purif
. 2024 Aug;
225:106582.
PMID: 39173964
Phosphatidylinositol 4,5-bisphosphate 3-kinases (PI3K) are a family of kinases whose activity affects pathways needed for basic cell functions. As a result, PI3K is one of the most mutated genes in...
4.
Smith M, Hernandez J, Messing S, Ramakrishnan N, Higgins B, Mehalko J, et al.
Microb Cell Fact
. 2024 Jul;
23(1):208.
PMID: 39049057
The diversity of chemical and structural attributes of proteins makes it inherently difficult to produce a wide range of proteins in a single recombinant protein production system. The nature of...
5.
Dyba M, Denson J, Maciag A
Methods Mol Biol
. 2024 Apr;
2797:145-157.
PMID: 38570458
MALDI-TOF mass spectrometry enables high-throughput screening of covalent fragment libraries and SAR compound progressions of selective KRAS G12C inhibitors. Using the MALDI-TOF platform instead of the more traditional ESI-MS TOF/orbitrap...
6.
Karkanitsa M, Li Y, Valenti S, Spathies J, Kelly S, Hunsberger S, et al.
medRxiv
. 2023 Oct;
PMID: 37904956
Due to a combination of asymptomatic or undiagnosed infections, the proportion of the United States population infected with SARS-CoV-2 was unclear from the beginning of the pandemic. We previously established...
7.
Kalish H, Klumpp-Thomas C, Hunsberger S, Baus H, Fay M, Siripong N, et al.
Sci Transl Med
. 2021 Jun;
13(601).
PMID: 34158410
Asymptomatic SARS-CoV-2 infection and delayed implementation of diagnostics have led to poorly defined viral prevalence rates in the United States and elsewhere. To address this, we analyzed seropositivity in 9089...
8.
Hicks J, Klumpp-Thomas C, Kalish H, Shunmugavel A, Mehalko J, Denson J, et al.
J Clin Immunol
. 2021 Mar;
41(5):906-913.
PMID: 33725211
In order to properly understand the spread of SARS-CoV-2 infection and development of humoral immunity, researchers have evaluated the presence of serum antibodies of people worldwide experiencing the pandemic. These...
9.
Tran T, Chan A, Young L, Bindu L, Neale C, Messing S, et al.
Nat Commun
. 2021 Feb;
12(1):1176.
PMID: 33608534
The first step of RAF activation involves binding to active RAS, resulting in the recruitment of RAF to the plasma membrane. To understand the molecular details of RAS-RAF interaction, we...
10.
Kalish H, Klumpp-Thomas C, Hunsberger S, Baus H, Fay M, Siripong N, et al.
medRxiv
. 2021 Feb;
PMID: 33532807
Asymptomatic SARS-CoV-2 infection and delayed implementation of diagnostics have led to poorly defined viral prevalence rates. To address this, we analyzed seropositivity in US adults who have not previously been...