Johan F Paulsson
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Explore the profile of Johan F Paulsson including associated specialties, affiliations and a list of published articles.
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22
Citations
670
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Recent Articles
1.
Ostergaard S, Paulsson J, Kofoed J, Zosel F, Olsen J, Jeppesen C, et al.
Sci Rep
. 2021 Oct;
11(1):21179.
PMID: 34707178
Peptides are notoriously known to display very short in vivo half-lives often measured in minutes which in many cases greatly reduces or eliminates sufficient in vivo efficacy. To obtain long...
2.
Poulsen C, Pedersen M, Wahlund P, Sjolander A, Thomsen J, Conde-Frieboes K, et al.
Pharm Res
. 2021 Jul;
38(8):1369-1385.
PMID: 34272643
Purpose: The anorectic effect of PYY makes it a potential pharmacological weight loss treatment. Modifications of the endogenous peptide to obtain commercially attractive pharmacological and biophysical stability properties are examined....
3.
Ostergaard S, Paulsson J, Gerstenberg M, Wulff B
Angew Chem Int Ed Engl
. 2021 Jan;
60(15):8268-8275.
PMID: 33448563
The two gut hormones GLP-1 and PYY , which are both secreted from the L-cells upon food stimuli, have a stronger inhibitory effect on food intake when they are combined,...
4.
Bolze F, Williams H, Bhuwania R, Egecioglu E, Bloem E, Paulsson J, et al.
Toxicol Appl Pharmacol
. 2020 Jul;
404:115152.
PMID: 32726590
Energy metabolism and reproduction are closely linked and reciprocally regulated. The detrimental effect of underweight on reproduction complicates the safety evaluation of anti-obesity drugs, making it challenging to distinguish pathological...
5.
Zouhar P, Rakipovski G, Bokhari M, Busby O, Paulsson J, Conde-Frieboes K, et al.
Am J Physiol Endocrinol Metab
. 2019 Nov;
318(1):E72-E86.
PMID: 31743040
The possibility to use leptin therapeutically for lowering glucose levels in patients with type 1 diabetes has attracted interest. However, earlier animal models of type 1 diabetes are severely catabolic...
6.
Ostergaard S, Kofoed J, Paulsson J, Madsen K, Jorgensen R, Wulff B
J Med Chem
. 2018 Nov;
61(23):10519-10530.
PMID: 30399314
In recent years peptide YY (PYY) has attracted attention within the area of diabetes and obesity due to its involvement in food intake regulation and glucose homeostasis. It is well-known...
7.
Madhivanan K, Greiner E, Alves-Ferreira M, Soriano-Castell D, Rouzbeh N, Aguirre C, et al.
Proc Natl Acad Sci U S A
. 2018 Aug;
115(33):E7710-E7719.
PMID: 30061394
Cell-autonomous and cell-nonautonomous mechanisms of neurodegeneration appear to occur in the proteinopathies, including Alzheimer's and Parkinson's diseases. However, how neuronal toxicity is generated from misfolding-prone proteins secreted by nonneuronal tissues...
8.
Xu B, Vasile S, Ostergaard S, Paulsson J, Pruner J, Aqvist J, et al.
Mol Pharmacol
. 2018 Jan;
93(4):323-334.
PMID: 29367257
Understanding the agonist-receptor interactions in the neuropeptide Y (NPY)/peptide YY (PYY) signaling system is fundamental for the design of novel modulators of appetite regulation. We report here the results of...
9.
Oskarsson M, Paulsson J, Schultz S, Ingelsson M, Westermark P, Westermark G
Am J Pathol
. 2015 Feb;
185(3):834-46.
PMID: 25700985
Several proteins have been identified as amyloid forming in humans, and independent of protein origin, the fibrils are morphologically similar. Therefore, there is a potential for structures with amyloid seeding...
10.
Albertsen L, Andersen J, Paulsson J, Thomsen J, Norrild J, Stromgaard K
ACS Med Chem Lett
. 2014 Jun;
4(12):1228-32.
PMID: 24900634
Peptide YY (PYY) is a gut hormone that activates the G protein-coupled neuropeptide Y (NPY) receptors, and because of its appetite reducing actions, it is evaluated as an antiobesity drug...