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Johan F Paulsson

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Articles 22
Citations 670
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Recent Articles
11.
Paulsson J, Ludvigsson J, Carlsson A, Casas R, Forsander G, Ivarsson S, et al.
PLoS One . 2014 Mar; 9(3):e93053. PMID: 24671002
Aims/hypothesis: Islet amyloid polypeptide (IAPP) is a beta cell hormone secreted together with insulin upon glucose stimulation. IAPP participates in normal glucose regulation, but IAPP is also known for its...
12.
Albertsen L, Ostergaard S, Paulsson J, Norrild J, Stromgaard K
ChemMedChem . 2013 Aug; 8(9):1505-13, 1422. PMID: 23907926
The gut hormone peptide YY (PYY) is postprandially secreted from enteroendocrine L cells and is involved in the regulation of energy homeostasis. The N-terminal truncated version PYY(3-36) decreases food intake...
13.
Pedersen S, Bhatia V, Jurt S, Paulsson J, Pedersen M, Jorgensen R, et al.
J Pept Sci . 2012 Aug; 18(9):579-87. PMID: 22865741
It has been hypothesized that amphipathic peptides might bind to membranes prior to activating their cognate receptors, but this has proven difficult to test. The peptide hormone PYY3-36 is believed...
14.
Paulsson J, Benoit-Biancamano M, Schaffer L, Dahl K
Amyloid . 2011 Nov; 18(4):222-8. PMID: 22047620
Diabetes in the domestic ferret (Mustela putorius furo) has previously been described and the purpose of this study was to evaluate if the ferret could serve as a model for...
15.
Lee A, Paulsson J, Cruite J, Andaya A, Trifilo M, Oldstone M
Virology . 2011 Jan; 411(1):1-8. PMID: 21227476
Earlier studies indicated that transgenic (tg) mice engineered to express prion protein (PrP) lacking the glycophosphatidylinositol (GPI⁻/⁻) membrane anchor formed abnormal proteinase-resistant prion (PrPsc) amyloid deposits in their brains and...
16.
Cohen E, Paulsson J, Blinder P, Burstyn-Cohen T, Du D, Estepa G, et al.
Cell . 2009 Dec; 139(6):1157-69. PMID: 20005808
The insulin/insulin growth factor (IGF) signaling (IIS) pathway is a key regulator of aging of worms, flies, mice, and likely humans. Delayed aging by IIS reduction protects the nematode C....
17.
Koob A, Ubhi K, Paulsson J, Kelly J, Rockenstein E, Mante M, et al.
Exp Neurol . 2009 Dec; 221(2):267-74. PMID: 19944097
Alpha-synuclein (alpha-syn) aggregation is a neuropathological hallmark of many diseases including Dementia with Lewy Bodies (DLB) and Parkinson's Disease (PD), collectively termed the alpha-synucleinopathies. The mechanisms underlying alpha-syn aggregation remain...
18.
Usui K, Hulleman J, Paulsson J, Siegel S, Powers E, Kelly J
Proc Natl Acad Sci U S A . 2009 Oct; 106(44):18563-8. PMID: 19841277
Accumulation of amyloid beta-peptide (Abeta) and tau aggregates, possibly linked to age-associated deficiencies in protein homeostasis, appear to cause Alzheimer's disease. Schiff-base formation between Abeta and the aldehyde-bearing cholesterol oxidation...
19.
Andersson A, Bohman S, Borg L, Paulsson J, Schultz S, Westermark G, et al.
Exp Diabetes Res . 2009 Mar; 2008:562985. PMID: 19277203
Following the encouraging report of the Edmonton group, there was a rejuvenation of the islet transplantation field. After that, more pessimistic views spread when long-term results of the clinical outcome...
20.
Chisalita S, Lindstrom T, Eson Jennersjo P, Paulsson J, Westermark G, Olsson A, et al.
Acta Diabetol . 2008 Sep; 46(1):35-42. PMID: 18777156
Our aim was to study, at the same glycemic control, how treatment with either the insulin secretagogue repaglinide or exogenous insulin aspart affects endogenous insulin secretion, plasma insulin and IAPP...