Sebastian W Schultz
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Explore the profile of Sebastian W Schultz including associated specialties, affiliations and a list of published articles.
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21
Citations
1347
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Recent Articles
1.
Trachsel-Moncho L, Veroni C, Mathai B, Lapao A, Singh S, Asp N, et al.
J Cell Biol
. 2025 Mar;
224(5).
PMID: 40052924
We here identify the endosomal protein SNX10 as a negative regulator of piecemeal mitophagy of OXPHOS machinery components. In control conditions, SNX10 localizes to early endocytic compartments in a PtdIns3P-dependent...
2.
Migliano S, Schultz S, Wenzel E, Takats S, Liu D, Mork S, et al.
Autophagy
. 2023 Oct;
20(4):769-791.
PMID: 37840274
Activated transmembrane receptors continue to signal following endocytosis and are only silenced upon ESCRT-mediated internalization of the receptors into intralumenal vesicles (ILVs) of the endosomes. Accordingly, endosomes with dysfunctional receptor...
3.
Ng M, Charsou C, Lapao A, Singh S, Trachsel-Moncho L, Schultz S, et al.
Nat Commun
. 2022 Oct;
13(1):6283.
PMID: 36270994
During autophagy, cytosolic cargo is sequestered into double-membrane vesicles called autophagosomes. The contributions of specific lipids, such as cholesterol, to the membranes that form the autophagosome, remain to be fully...
4.
Munson M, Mathai B, Ng M, Trachsel-Moncho L, de la Ballina L, Schultz S, et al.
Nat Commun
. 2021 Oct;
12(1):6101.
PMID: 34671015
The mechanisms involved in programmed or damage-induced removal of mitochondria by mitophagy remains elusive. Here, we have screened for regulators of PRKN-independent mitophagy using an siRNA library targeting 197 proteins...
5.
Schultz S, Agudo-Canalejo J, Chino H, Migliano S, Saito C, Koyama-Honda I, et al.
Autophagy
. 2021 Feb;
17(4):1046-1048.
PMID: 33629888
Phase-separated droplets with liquid-like properties can be degraded by macroautophagy/autophagy, but the mechanism underlying this degradation is poorly understood. We have recently derived a physical model to investigate the interaction...
6.
Agudo-Canalejo J, Schultz S, Chino H, Migliano S, Saito C, Koyama-Honda I, et al.
Nature
. 2021 Jan;
591(7848):142-146.
PMID: 33473217
Compartmentalization of cellular material in droplet-like structures is a hallmark of liquid-liquid phase separation, but the mechanisms of droplet removal are poorly understood. Evidence suggests that droplets can be degraded...
7.
Ohnstad A, Delgado J, North B, Nasa I, Kettenbach A, Schultz S, et al.
EMBO J
. 2020 Nov;
39(24):e104948.
PMID: 33226137
Autophagosome formation requires multiple autophagy-related (ATG) factors. However, we find that a subset of autophagy substrates remains robustly targeted to the lysosome in the absence of several core ATGs, including...
8.
Liese S, Wenzel E, Kjos I, Rojas Molina R, Schultz S, Brech A, et al.
Proc Natl Acad Sci U S A
. 2020 Nov;
117(46):28614-28624.
PMID: 33139578
As part of the lysosomal degradation pathway, the endosomal sorting complexes required for transport (ESCRT-0 to -III/VPS4) sequester receptors at the endosome and simultaneously deform the membrane to generate intraluminal...
9.
Vietri M, Schultz S, Bellanger A, Jones C, Petersen L, Raiborg C, et al.
Nat Cell Biol
. 2020 Jul;
22(7):856-867.
PMID: 32601372
The ESCRT-III membrane fission machinery maintains the integrity of the nuclear envelope. Although primary nuclei resealing takes minutes, micronuclear envelope ruptures seem to be irreversible. Instead, micronuclear ruptures result in...
10.
Jakobi A, Huber S, Mortensen S, Schultz S, Palara A, Kuhm T, et al.
Nat Commun
. 2020 Jan;
11(1):440.
PMID: 31974402
p62/SQSTM1 is an autophagy receptor and signaling adaptor with an N-terminal PB1 domain that forms the scaffold of phase-separated p62 bodies in the cell. The molecular determinants that govern PB1...