Birgitte S Wulff
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Explore the profile of Birgitte S Wulff including associated specialties, affiliations and a list of published articles.
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28
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469
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Recent Articles
1.
Wulff B, Kuhre R, Selvaraj M, Rehfeld J, Niss K, Fels J, et al.
Heliyon
. 2024 Aug;
10(12):e32009.
PMID: 39183855
Objective: Co-treatment with long acting PYY and the GLP-1 receptor agonists has potential as an efficient obesity treatment. This study investigates whether the mechanisms behind additive reduction of food intake...
2.
Jacobsen J, Petersen N, Torz L, Gerstenberg M, Pedersen K, Ostergaard S, et al.
Cell Rep
. 2024 Jul;
43(8):114501.
PMID: 39067024
Evaluation of weight loss drugs is usually performed in diet-induced obese mice housed at ∼22°C. This is a cold stress that increases energy expenditure by ∼35% compared to thermoneutrality (∼30°C),...
3.
Mehrotra S, Lam S, Glenn E, Hymel D, Sanford C, Liu Q, et al.
ACS Bio Med Chem Au
. 2023 Apr;
2(4):370-375.
PMID: 37102164
Neuromedin-U (NMU) mediates several physiological functions via its two cognate receptors, NMUR1 and NMUR2. Disentangling the individual roles of each receptor has largely been undertaken through the use of transgenic...
4.
Ostergaard S, Paulsson J, Kofoed J, Zosel F, Olsen J, Jeppesen C, et al.
Sci Rep
. 2021 Oct;
11(1):21179.
PMID: 34707178
Peptides are notoriously known to display very short in vivo half-lives often measured in minutes which in many cases greatly reduces or eliminates sufficient in vivo efficacy. To obtain long...
5.
Poulsen C, Pedersen M, Wahlund P, Sjolander A, Thomsen J, Conde-Frieboes K, et al.
Pharm Res
. 2021 Jul;
38(8):1369-1385.
PMID: 34272643
Purpose: The anorectic effect of PYY makes it a potential pharmacological weight loss treatment. Modifications of the endogenous peptide to obtain commercially attractive pharmacological and biophysical stability properties are examined....
6.
John L, Dalsgaard C, Jeppesen C, Conde-Frieboes K, Baumann K, Knudsen N, et al.
J Immunotoxicol
. 2021 Feb;
18(1):30-36.
PMID: 33570451
In development of peptide therapeutics, rodents are commonly-used preclinical models when screening compounds for efficacy endpoints in the early stages of discovery projects. During the screening process, some peptides administered...
7.
Ostergaard S, Paulsson J, Gerstenberg M, Wulff B
Angew Chem Int Ed Engl
. 2021 Jan;
60(15):8268-8275.
PMID: 33448563
The two gut hormones GLP-1 and PYY , which are both secreted from the L-cells upon food stimuli, have a stronger inhibitory effect on food intake when they are combined,...
8.
Bolze F, Williams H, Bhuwania R, Egecioglu E, Bloem E, Paulsson J, et al.
Toxicol Appl Pharmacol
. 2020 Jul;
404:115152.
PMID: 32726590
Energy metabolism and reproduction are closely linked and reciprocally regulated. The detrimental effect of underweight on reproduction complicates the safety evaluation of anti-obesity drugs, making it challenging to distinguish pathological...
9.
Viuff B, Straarup E, Nowak J, Morgills L, Skydsgaard M, Sjogren I, et al.
Toxicol Pathol
. 2019 Oct;
48(2):379-392.
PMID: 31645215
Pigs are used as a model of human obesity, both for metabolic characterization and for evaluation of pharmacological interventions. Over a period of 7 years, acute death or clinical signs...
10.
Jones E, Nunn N, Chambers A, Ostergaard S, Wulff B, Luckman S
Endocrinology
. 2019 May;
160(11):2737-2747.
PMID: 31074796
To study the effects of an analog of the gut-produced hormone peptide YY (PYY3-36), which has increased selectivity for the Y2 receptor; specifically, to record its effects on food intake...