Joao Paulo S Fernandes
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Explore the profile of Joao Paulo S Fernandes including associated specialties, affiliations and a list of published articles.
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32
Citations
85
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Recent Articles
1.
Brito I, Castro Levatti E, Regasini L, Ferreira E, Lopes F, Fernandes J, et al.
Phytochemistry
. 2024 Dec;
231():114360.
PMID: 39672219
As part of our continuous study on the Annonaceae species Porcelia macrocarpa, in the present work, eight chemically related 2-alkyl-3-hydroxy-4-methyl-γ-lactones (1-8) were isolated. Their structures were characterised by NMR, MS,...
2.
Lopes F, Fernandes J, Uliassi E
Curr Top Med Chem
. 2024 Aug;
24(28):2421-2430.
PMID: 39185652
Neuroinflammation is a process involved in a variety of central nervous system (CNS) diseases and is being increasingly recognized as a key mediator of cognitive impairments. Neuroinflammatory responses including glial...
3.
Roquini D, Lemes B, Kreutz A, Spoladore S, Amaro M, Lopes F, et al.
ACS Omega
. 2024 Jul;
9(28):31159-31165.
PMID: 39035884
Infections caused by parasitic helminths pose significant health concerns for both humans and animals. The limited efficacy of existing drugs underscores the urgent need for novel anthelmintic agents. Given the...
4.
Lippi B, Fernandes G, Azevedo G, Negreiros N, Soares A, Landgraf M, et al.
Int Immunopharmacol
. 2024 Apr;
133:112128.
PMID: 38652966
Ulcerative colitis (UC) is a chronic inflammatory bowel disease with growing incidence worldwide. Our group reported the compound 5-choro-1-[(2,3-dihydro-1-benzofuran-2-yl)methyl]piperazine (LINS01007) as HR antagonist (pK 6.2) and therefore the effects and...
5.
Varela M, de Castro Levatti E, Tempone A, Fernandes J
ACS Omega
. 2023 Nov;
8(46):44265-44275.
PMID: 38027351
Melanin is a substance that plays important roles in several organisms. Its function as an antioxidant and metal-complexing agent makes tyrosinase, the key enzyme that controls melanogenesis, an interesting target...
6.
Varela M, Romanelli M, Amaral M, Tempone A, Fernandes J
Saudi Pharm J
. 2023 Jun;
31(7):1265-1273.
PMID: 37287509
The absence of effective chronic treatment, expansion to non-endemic countries and the significant burden in public health have stimulated the search for novel therapeutic options to treat Chagas disease, a...
7.
Amaral M, Varela M, Kant R, Christodoulides M, Fernandes J, Tempone A
Life (Basel)
. 2023 Mar;
13(3).
PMID: 36983820
Chagas disease is an endemic tropical disease caused by the protozoan , which affects around 7 million people worldwide, mostly in development countries. The treatment relies on only two available...
8.
Mengarda A, Silva T, Silva A, Roquini D, Fernandes J, de Moraes J
Eur J Med Chem
. 2023 Mar;
251:115268.
PMID: 36921525
Infections caused by parasitic helminths rank among the most prevalent infections of humans and animals. Toxocariasis, caused by nematodes of the genus Toxocara, is one of the most widespread and...
9.
Carmo-Martins J, Gonzatti M, Varela M, Sousa M, Costa L, Rodrigues E, et al.
Biomedicines
. 2023 Jan;
11(1).
PMID: 36672704
Previous studies reported that p-coumaric acid modulates melanoma growth. Because the esterification of p-coumaric acid (p-CA) enhanced its activity as an antimelanogenic agent, we aimed to determine the antitumor potential...
10.
de Castro Levatti E, Costa-Silva T, Morais T, Fernandes J, Lago J, Tempone A
Biochimie
. 2022 Dec;
208:141-150.
PMID: 36586562
Natural metabolites present an extraordinary chemo-diversity and have been used as the inspiration for new drugs. Considering the need for new treatments against the neglected parasitic disease leishmaniasis, three semi-synthetic...