Andre G Tempone
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Explore the profile of Andre G Tempone including associated specialties, affiliations and a list of published articles.
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Recent Articles
1.
Tempone A, Abiuzi M, de Andrade B, Ramos F, Totini C, Christodoulides M, et al.
Chem Biodivers
. 2025 Feb;
:e202403109.
PMID: 40013743
Chagas disease is a parasitic disease with approximately 8 million people infected worldwide, presenting a limited and toxic treatment. Comprising a vast chemodiversity, microbial metabolites are among the most important...
2.
Gomes K, Costa-Silva T, Borges W, Andrade B, Ferreira D, Tempone A, et al.
ACS Omega
. 2025 Feb;
10(3):3025-3032.
PMID: 39895773
The EtOAc extract from bulbs of (Amaryllidaceae) exhibited antiprotozoal activity against and afforded the alkaloids narciclasine (), 7-deoxynarciclasine (), and narciclasine-4-O-β-D-xylopyranoside (). studies showed adequate predictions for drug-likeness for alkaloids...
3.
Brito I, Castro Levatti E, Regasini L, Ferreira E, Lopes F, Fernandes J, et al.
Phytochemistry
. 2024 Dec;
231():114360.
PMID: 39672219
As part of our continuous study on the Annonaceae species Porcelia macrocarpa, in the present work, eight chemically related 2-alkyl-3-hydroxy-4-methyl-γ-lactones (1-8) were isolated. Their structures were characterised by NMR, MS,...
4.
da Silva G, Dos Santos K, Barcellos A, de Sousa R, Tempone A, Lago J, et al.
Bioorg Chem
. 2024 Nov;
153:107941.
PMID: 39522426
A natural product isolated from Brazilian plant species Baccharis retusa (Asteraceae), 15β-senecioyloxi-ent-kaurenoic acid (1), demonstrated activity against trypomastigotes of the parasite Trypanosoma cruzi but it was inactive against intracellular forms....
5.
Amaral M, Romanelli M, Asiki H, Bicker J, Lage D, Freitas C, et al.
Antimicrob Agents Chemother
. 2024 Oct;
68(11):e0083124.
PMID: 39382276
Leishmaniasis is a parasitic neglected tropical disease, affecting 12 million people. Available treatments present several limitations, with an increasing number of resistance cases. In the search for new chemotherapies, the...
6.
Tristao D, Barbosa H, de Castro Levatti E, Andrade B, Romanelli M, Antar G, et al.
Chem Biodivers
. 2024 Jun;
21(9):e202401247.
PMID: 38896778
As part of our continuous research for the discovery of bioactive compounds against Trypanosoma cruzi and Leishmania infantum, the alkaloid (6aS)-dicentrine (1) was oxidized to afford (6aS,6S)- (2) and (6aS,6R)-...
7.
Rosa M, Tristao D, Barbosa H, Mendes V, Tempone A, Lago J, et al.
Bioorg Chem
. 2024 Apr;
147:107408.
PMID: 38678776
This study aimed to assess the antiprotozoal efficacy of dicentrine, an aporphine alkaloid isolated from Ocotea puberula, against amastigote forms of Leishmania (L.) infantum. Our findings reveal that dicentrine demonstrated...
8.
Peres N, Silva M, Ueno A, Antar G, Levatti E, Tempone A, et al.
Nat Prod Res
. 2024 Mar;
:1-7.
PMID: 38538549
In the present work, the hexane extract of aerial parts of Kunth. was subjected to chromatographic fractionation to afford two alkyl phenylpropanoids: -docosyl (-coumarate () and -tetracosyl -coumarate () as...
9.
de M Goncalves M, Totini C, De Castro E, Albuquerque V, Antar G, Tempone A, et al.
Chem Biodivers
. 2024 Mar;
21(5):e202400547.
PMID: 38507773
The hexane extract from twigs of Piper truncatum Vell (Piperaceae) displayed activity against Trypanosoma cruzi and was subjected to chromatographic steps to afford six dibenzylbutyrolactolic lignans, being four knowns: cubebin...
10.
Sozanschi A, Asiki H, Amaral M, de Castro Levatti E, Tempone A, Wheeler R, et al.
JACS Au
. 2024 Mar;
4(2):847-854.
PMID: 38425909
Visceral leishmaniasis and Chagas disease are neglected tropical diseases (NTDs) that severely impact the developing world. With current therapies suffering from poor efficacy and safety profiles as well as emerging...