Joao-Paulo Camporez
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Explore the profile of Joao-Paulo Camporez including associated specialties, affiliations and a list of published articles.
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11
Citations
2094
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Recent Articles
1.
Han M, Perry R, Camporez J, Scherer P, Shulman G, Gao G, et al.
Genes Dev
. 2020 Dec;
35(1-2):133-146.
PMID: 33334822
The cJun NH-terminal kinase (JNK) signaling pathway is activated by metabolic stress and promotes the development of metabolic syndrome, including hyperglycemia, hyperlipidemia, and insulin resistance. This integrated physiological response involves...
2.
Wang L, Sinnott-Armstrong N, Wagschal A, Wark A, Camporez J, Perry R, et al.
Cell
. 2020 Oct;
183(3):684-701.e14.
PMID: 33058756
Positive selection in Europeans at the 2q21.3 locus harboring the lactase gene has been attributed to selection for the ability of adults to digest milk to survive famine in ancient...
3.
Abulizi A, Vatner D, Ye Z, Wang Y, Camporez J, Zhang D, et al.
J Lipid Res
. 2020 Sep;
61(12):1565-1576.
PMID: 32907986
Microsomal triglyceride transfer protein (MTTP) deficiency results in a syndrome of hypolipidemia and accelerated NAFLD. Animal models of decreased hepatic MTTP activity have revealed an unexplained dissociation between hepatic steatosis...
4.
Han M, White A, Perry R, Camporez J, Hidalgo J, Shulman G, et al.
Proc Natl Acad Sci U S A
. 2020 Jan;
117(6):2751-2760.
PMID: 31980524
Obesity is associated with a chronic state of low-grade inflammation and progressive tissue infiltration by immune cells and increased expression of inflammatory cytokines. It is established that interleukin 6 (IL6)...
5.
Zhao L, Pascual F, Bacudio L, Suchanek A, Young P, Li L, et al.
J Biol Chem
. 2019 Apr;
294(22):8819-8833.
PMID: 30975900
Loss of long-chain acyl-CoA synthetase isoform-1 (ACSL1) in mouse skeletal muscle () severely reduces acyl-CoA synthetase activity and fatty acid oxidation. However, the effects of decreased fatty acid oxidation on...
6.
Abulizi A, Camporez J, Jurczak M, Hoyer K, Zhang D, Cline G, et al.
FASEB J
. 2019 Mar;
33(7):8174-8185.
PMID: 30922125
The connection between adipose glucocorticoid action and whole-body metabolism is incompletely understood. Thus, we generated adipose tissue-specific glucocorticoid receptor-knockout (Ad-GcR) mice to explore potential mechanisms. Ad-GcR mice had a lower...
7.
Abulizi A, Camporez J, Zhang D, Samuel V, Shulman G, Vatner D
Metabolism
. 2018 Dec;
93:1-9.
PMID: 30576689
Context: Excessive adipose glucocorticoid action is associated with insulin resistance, but the mechanisms linking adipose glucocorticoid action to insulin resistance are still debated. We hypothesized that insulin resistance from excess...
8.
Aryal B, Singh A, Zhang X, Varela L, Rotllan N, Goedeke L, et al.
JCI Insight
. 2018 Mar;
3(6).
PMID: 29563332
Alterations in ectopic lipid deposition and circulating lipids are major risk factors for developing cardiometabolic diseases. Angiopoietin-like protein 4 (ANGPTL4), a protein that inhibits lipoprotein lipase (LPL), controls fatty acid...
9.
Price N, Singh A, Rotllan N, Goedeke L, Wing A, Canfran-Duque A, et al.
Cell Rep
. 2018 Feb;
22(8):2133-2145.
PMID: 29466739
While therapeutic modulation of miRNAs provides a promising approach for numerous diseases, the promiscuous nature of miRNAs raises concern over detrimental off-target effects. miR-33 has emerged as a likely target...
10.
Madiraju A, Erion D, Rahimi Y, Zhang X, Braddock D, Albright R, et al.
Nature
. 2014 May;
510(7506):542-6.
PMID: 24847880
Metformin is considered to be one of the most effective therapeutics for treating type 2 diabetes because it specifically reduces hepatic gluconeogenesis without increasing insulin secretion, inducing weight gain or...