Joanna R DiSpirito
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Explore the profile of Joanna R DiSpirito including associated specialties, affiliations and a list of published articles.
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14
Citations
776
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Recent Articles
1.
Hall J, Ramachandran D, Roh H, DiSpirito J, Belchior T, Zushin P, et al.
Cell Metab
. 2020 Sep;
32(4):665-675.e6.
PMID: 32941798
The thiazolidinediones (TZDs) are ligands of PPARγ that improve insulin sensitivity, but their use is limited by significant side effects. Recently, we demonstrated a mechanism wherein TZDs improve insulin sensitivity...
2.
DiSpirito J, Zemmour D, Ramanan D, Cho J, Zilionis R, Klein A, et al.
Sci Immunol
. 2018 Sep;
3(27).
PMID: 30217811
Foxp3CD4 regulatory T cells (T) accumulate in certain nonlymphoid tissues, where they control diverse aspects of organ homeostasis. Populations of tissue T, as they have been termed, have transcriptomes distinct...
3.
Nelson V, Nguyen H, Garcia-Canaveras J, Briggs E, Ho W, DiSpirito J, et al.
Genes Dev
. 2018 Jul;
32(15-16):1035-1044.
PMID: 30006480
The nuclear receptor peroxisome proliferator-activated receptor γ (PPARγ) is known to regulate lipid metabolism in many tissues, including macrophages. Here we report that peritoneal macrophage respiration is enhanced by rosiglitazone,...
4.
Li C, DiSpirito J, Zemmour D, Spallanzani R, Kuswanto W, Benoist C, et al.
Cell
. 2018 Jun;
174(2):285-299.e12.
PMID: 29887374
Visceral adipose tissue (VAT) hosts a population of regulatory T (Treg) cells, with a unique phenotype, that controls local and systemic inflammation and metabolism. Generation of a T cell receptor...
5.
Soccio R, Li Z, Chen E, Foong Y, Benson K, DiSpirito J, et al.
J Clin Invest
. 2017 Feb;
127(4):1451-1462.
PMID: 28240605
Obesity causes insulin resistance, and PPARγ ligands such as rosiglitazone are insulin sensitizing, yet the mechanisms remain unclear. In C57BL/6 (B6) mice, obesity induced by a high-fat diet (HFD) has...
6.
Yang C, Khanniche A, DiSpirito J, Ji P, Wang S, Wang Y, et al.
Sci Rep
. 2016 Jun;
6:27005.
PMID: 27243788
Memory T cells (TM) play a prominent role in protection and auto-immunity due to their ability to mount a more effective response than naïve T cells (TN). However, the molecular...
7.
DiSpirito J, Mathis D
Semin Immunol
. 2015 Dec;
27(5):315-21.
PMID: 26616665
Adipose tissue is composed of many functionally and developmentally distinct cell types, the metabolic core of which is the adipocyte. The classification of "adipocyte" encompasses three primary types - white,...
8.
Soccio R, Chen E, Rajapurkar S, Safabakhsh P, Marinis J, DiSpirito J, et al.
Cell
. 2015 Jul;
162(1):33-44.
PMID: 26140591
SNPs affecting disease risk often reside in non-coding genomic regions. Here, we show that SNPs are highly enriched at mouse strain-selective adipose tissue binding sites for PPARγ, a nuclear receptor...
9.
Zhang F, Zhou X, DiSpirito J, Wang C, Wang Y, Shen H
Mol Ther
. 2014 May;
22(9):1698-706.
PMID: 24861055
Functional exhaustion of antigen-specific T cells is a defining characteristic of many chronic infections, but the underlying mechanisms of T cell dysfunction are not well understood. Epigenetics plays an important...
10.
Wang F, Mullican S, DiSpirito J, Peed L, Lazar M
Proc Natl Acad Sci U S A
. 2013 Oct;
110(46):18656-61.
PMID: 24167256
Adipose tissue is an important metabolic organ, the dysfunction of which is associated with the development of obesity, diabetes mellitus, and cardiovascular disease. The nuclear receptor peroxisome proliferator-activated receptor gamma...