Joan W Conaway
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Explore the profile of Joan W Conaway including associated specialties, affiliations and a list of published articles.
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4431
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Recent Articles
31.
Sardiu M, Gilmore J, Groppe B, Herman D, Ramisetty S, Cai Y, et al.
EMBO Rep
. 2014 Nov;
16(1):116-26.
PMID: 25427557
The study of conserved protein interaction networks seeks to better understand the evolution and regulation of protein interactions. Here, we present a quantitative proteomic analysis of 18 orthologous baits from...
32.
Chen L, Ooi S, Conaway J, Conaway R
J Vis Exp
. 2014 Nov;
(92):e51721.
PMID: 25407555
Members of the SNF2 family of ATPases often function as components of multi-subunit chromatin remodeling complexes that regulate nucleosome dynamics and DNA accessibility by catalyzing ATP-dependent nucleosome remodeling. Biochemically dissecting...
33.
Chen L, Ooi S, Conaway R, Conaway J
J Vis Exp
. 2014 Nov;
(92):e51720.
PMID: 25407439
INO80 chromatin remodeling complexes regulate nucleosome dynamics and DNA accessibility by catalyzing ATP-dependent nucleosome remodeling. Human INO80 complexes consist of 14 protein subunits including Ino80, a SNF2-like ATPase, which serves...
34.
Tsai K, Tomomori-Sato C, Sato S, Conaway R, Conaway J, Asturias F
Cell
. 2014 Jun;
157(6):1430-1444.
PMID: 24882805
The multisubunit Mediator, comprising ∼30 distinct proteins, plays an essential role in gene expression regulation by acting as a bridge between DNA-binding transcription factors and the RNA polymerase II (RNAPII)...
35.
Chen L, Conaway R, Conaway J
Proc Natl Acad Sci U S A
. 2013 Dec;
110(51):20497-502.
PMID: 24297934
SNF2 family ATPases are ATP-dependent motors that often function in multisubunit complexes to regulate chromatin structure. Although the central role of SNF2 ATPases in chromatin biology is well established, mechanisms...
36.
Zhao X, Su J, Wang F, Liu D, Ding J, Yang Y, et al.
PLoS Genet
. 2013 Nov;
9(11):e1003940.
PMID: 24244196
hMOF (MYST1), a histone acetyltransferase (HAT), forms at least two distinct multiprotein complexes in human cells. The male specific lethal (MSL) HAT complex plays a key role in dosage compensation...
37.
Kawauchi J, Inoue M, Fukuda M, Uchida Y, Yasukawa T, Conaway R, et al.
J Biol Chem
. 2013 Jul;
288(34):24302-15.
PMID: 23828199
Elongin A was shown previously to be capable of potently activating the rate of RNA polymerase II (RNAPII) transcription elongation in vitro by suppressing transient pausing by the enzyme at...
38.
A conserved Mediator-CDK8 kinase module association regulates Mediator-RNA polymerase II interaction
Tsai K, Sato S, Tomomori-Sato C, Conaway R, Conaway J, Asturias F
Nat Struct Mol Biol
. 2013 Apr;
20(5):611-9.
PMID: 23563140
The CDK8 kinase module (CKM) is a conserved, dissociable Mediator subcomplex whose component subunits were genetically linked to the RNA polymerase II (RNAPII) C-terminal domain (CTD) and individually recognized as...
39.
Tomomori-Sato C, Sato S, Conaway R, Conaway J
Methods Mol Biol
. 2013 Feb;
977:273-87.
PMID: 23436370
In this chapter, we describe a purification scheme designed to isolate multisubunit protein complexes gently and quickly from crude extracts of mammalian cells using immunoaffinity purification of epitope tagged proteins...
40.
Gottschalk A, Trivedi R, Conaway J, Conaway R
J Biol Chem
. 2012 Nov;
287(52):43527-32.
PMID: 23132853
The human ALC1/CHD1L oncogene encodes an SNF2 family ATPase with a macrodomain that binds poly(ADP-ribose) (PAR). We and others previously showed that ALC1 possesses a cryptic ATP-dependent nucleosome remodeling activity...