Jimmy A Blair
Overview
Explore the profile of Jimmy A Blair including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
9
Citations
496
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Vo C, Shebert H, Zikovich S, Dryer R, Huang T, Moran L, et al.
Bioorg Med Chem Lett
. 2017 Nov;
27(23):5235-5244.
PMID: 29110989
To address the growing need for new antimicrobial agents, we explored whether inhibition of bacterial signaling machinery could inhibit bacterial growth. Because bacteria rely on two-component signaling systems to respond...
2.
Mann T, Childers W, Blair J, Eckart M, Shapiro L
Nat Commun
. 2016 Apr;
7:11454.
PMID: 27117914
All cells must integrate sensory information to coordinate developmental events in space and time. The bacterium Caulobacter crescentus uses two-component phospho-signalling to regulate spatially distinct cell cycle events through the...
3.
Stott K, Wood S, Blair J, Nguyen B, Herrera A, Mora Y, et al.
Microbiology (Reading)
. 2015 Jan;
161(Pt 3):553-64.
PMID: 25573769
Stress conditions, such as a block in fatty acid synthesis, signal bacterial cells to exit the cell cycle. Caulobacter crescentus FabH is a cell-cycle-regulated β-ketoacyl-acyl carrier protein synthase that initiates...
4.
Childers W, Xu Q, Mann T, Mathews I, Blair J, Deacon A, et al.
PLoS Biol
. 2014 Oct;
12(10):e1001979.
PMID: 25349992
One of the simplest organisms to divide asymmetrically is the bacterium Caulobacter crescentus. The DivL pseudo-histidine kinase, positioned at one cell pole, regulates cell-fate by controlling the activation of the...
5.
Blair J, Xu Q, Childers W, Mathews I, Kern J, Eckart M, et al.
Structure
. 2013 Aug;
21(9):1590-601.
PMID: 23932593
Vital to bacterial survival is the faithful propagation of cellular signals, and in Caulobacter crescentus, ChpT is an essential mediator within the cell-cycle circuit. ChpT functions as a histidine-containing phosphotransfer...
6.
Barkovich K, Hariono S, Garske A, Zhang J, Blair J, Fan Q, et al.
Cancer Discov
. 2012 May;
2(5):450-7.
PMID: 22588882
Unlabelled: Although mutational activation of the epidermal growth factor receptor (EGFR) features prominently in glioma and non-small cell lung cancer (NSCLC), inhibitors of EGFR improve survival only in patients with...
7.
Amin D, Sergina N, Ahuja D, McMahon M, Blair J, Wang D, et al.
Sci Transl Med
. 2010 Apr;
2(16):16ra7.
PMID: 20371474
About 25% of breast cancers harbor the amplified oncogene human epidermal growth factor receptor 2 (HER2) and are dependent on HER2 kinase function, identifying HER2 as a vulnerable target for...
8.
Apsel B, Blair J, Gonzalez B, Nazif T, Feldman M, Aizenstein B, et al.
Nat Chem Biol
. 2008 Oct;
4(11):691-9.
PMID: 18849971
The clinical success of multitargeted kinase inhibitors has stimulated efforts to identify promiscuous drugs with optimal selectivity profiles. It remains unclear to what extent such drugs can be rationally designed,...
9.
Blair J, Rauh D, Kung C, Yun C, Fan Q, Rode H, et al.
Nat Chem Biol
. 2007 Mar;
3(4):229-38.
PMID: 17334377
As key components in nearly every signal transduction pathway, protein kinases are attractive targets for the regulation of cellular signaling by small-molecule inhibitors. We report the structure-guided development of 6-acrylamido-4-anilinoquinazoline...