Roger L Williams
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Explore the profile of Roger L Williams including associated specialties, affiliations and a list of published articles.
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124
Citations
8602
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Recent Articles
1.
Tomlinson P, Knox R, Perisic O, Su H, Brierley G, Williams R, et al.
Elife
. 2025 Jan;
13.
PMID: 39835783
encodes three regulatory subunits of class IA phosphoinositide 3-kinase (PI3K), each associating with any of three catalytic subunits, namely p110α, p110β, or p110δ. Constitutional mutations cause diseases with a genotype-phenotype...
2.
Gong G, Anandapadamanaban M, Islam M, Hay I, Bourguet M, Spokaite S, et al.
Adv Biol Regul
. 2024 Nov;
95:101060.
PMID: 39592347
The phosphoinositide 3-kinase (PI3K) superfamily includes lipid kinases (PI3Ks and type III PI4Ks) and a group of PI3K-like Ser/Thr protein kinases (PIKKs: mTOR, ATM, ATR, DNA-PKcs, SMG1 and TRRAP) that...
3.
Gong G, Masson G, Lee W, Dickson J, Kendall J, Rathinaswamy M, et al.
Biochem J
. 2024 Nov;
481(23):1787-1802.
PMID: 39485310
PI3Kα, consisting of the p110α isoform of the catalytic subunit of PI 3-kinase (encoded by PIK3CA) and the p85α regulatory subunit (encoded by PI3KR1) is activated by growth factor receptors....
4.
Swamynathan M, Kuang S, Watrud K, Doherty M, Gineste C, Mathew G, et al.
Science
. 2024 Oct;
386(6720):eadk9167.
PMID: 39446948
Men taking antioxidant vitamin E supplements have increased prostate cancer (PC) risk. However, whether pro-oxidants protect from PC remained unclear. In this work, we show that a pro-oxidant vitamin K...
5.
Pacyna C, Anandapadamanaban M, Loudon K, Hay I, Perisic O, Li R, et al.
Oncogene
. 2024 Sep;
43(44):3268-3276.
PMID: 39271965
Embryogenesis is a vulnerable time. Mutations in developmental cells can result in the wide dissemination of cells predisposed to disease within mature organs. We characterised the evolutionary history of four...
6.
Tomlinson P, Knox R, Perisic O, Su H, Brierley G, Williams R, et al.
bioRxiv
. 2023 Dec;
PMID: 38077044
encodes three regulatory subunits of class IA phosphoinositide 3-kinase (PI3K), each associating with any of three catalytic subunits, namely p110α, p110β or p110δ. Constitutional mutations cause diseases with a genotype-phenotype...
7.
Howes A, Perisic O, Williams R
Sci Adv
. 2023 Sep;
9(39):eadi8291.
PMID: 37756394
Ataxia-telangiectasia mutated (ATM) is a master kinase regulating DNA damage response that is activated by DNA double-strand breaks. However, ATM is also directly activated by reactive oxygen species, but how...
8.
Gong G, Bilanges B, Allsop B, Masson G, Roberton V, Askwith T, et al.
Nature
. 2023 May;
618(7963):159-168.
PMID: 37225977
Harnessing the potential beneficial effects of kinase signalling through the generation of direct kinase activators remains an underexplored area of drug development. This also applies to the PI3K signalling pathway,...
9.
Rathinaswamy M, Jenkins M, Duewell B, Zhang X, Harris N, Evans J, et al.
Cell Rep
. 2023 Feb;
42(3):112172.
PMID: 36842083
Class IB phosphoinositide 3-kinase (PI3Kγ) is activated in immune cells and can form two distinct complexes (p110γ-p84 and p110γ-p101), which are differentially activated by G protein-coupled receptors (GPCRs) and Ras....
10.
Lo W, Belabed H, Kucukdisli M, Metag J, Roske Y, Prokofeva P, et al.
Nat Chem Biol
. 2022 Sep;
19(1):18-27.
PMID: 36109648
Phosphatidylinositol 3-kinase type 2α (PI3KC2α) and related class II PI3K isoforms are of increasing biomedical interest because of their crucial roles in endocytic membrane dynamics, cell division and signaling, angiogenesis,...