Jie Xin Tong
Overview
Explore the profile of Jie Xin Tong including associated specialties, affiliations and a list of published articles.
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Articles
7
Citations
42
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Recent Articles
1.
Chia W, Gomez-Lorenzo M, Castellote I, Tong J, Chandramohanadas R, Thu Chu T, et al.
ACS Chem Biol
. 2021 Oct;
16(11):2348-2372.
PMID: 34609851
The search for new antimalarial drugs with unexplored mechanisms of action is currently one of the main objectives to combat the resistance already in the clinic. New drugs should target...
2.
Ahenkorah S, Coertzen D, Tong J, Fridianto K, Wittlin S, Birkholtz L, et al.
ACS Med Chem Lett
. 2020 Jan;
11(1):49-55.
PMID: 31938463
Here we report the nanomolar potencies of , -dialkyldioxonaphthoimidazoliums against asexual forms of sensitive and resistant . Activity was dependent on the presence of the fused quinone-imidazolium entity and lipophilicity...
3.
Soumyanarayanan U, Ramanujulu P, Mustafa N, Haider S, Nee A, Tong J, et al.
Eur J Med Chem
. 2019 Oct;
184:111755.
PMID: 31627059
Herein, we report the discovery of a dual histone deacetylase inhibitor displaying a unique HDAC3/6 selectivity profile. An initial strategy to merge two epigenetic pharmacophores resulted in the discovery of...
4.
Subramanian G, Belekar M, Shukla A, Tong J, Sinha A, Chu T, et al.
mSphere
. 2019 Mar;
4(2).
PMID: 30867329
No abstract available.
5.
Tong J, Ang S, Tan E, Tan K
Antimicrob Agents Chemother
. 2019 Feb;
63(4).
PMID: 30718250
The emergence of artemisinin-resistant poses a major threat to current frontline artemisinin combination therapies. Artemisinin resistance is widely associated with mutations in the Kelch13 (PfKelch13) propeller region, leading to delayed...
6.
Subramanian G, Belekar M, Shukla A, Tong J, Sinha A, Chu T, et al.
mSphere
. 2018 Jan;
3(1).
PMID: 29359192
The Malaria Box collection includes 400 chemically diverse small molecules with documented potency against malaria parasite growth, but the underlying modes of action are largely unknown. Using complementary phenotypic screens...
7.
Tong J, Chandramohanadas R, Tan K
Antimicrob Agents Chemother
. 2018 Jan;
62(3).
PMID: 29311064
infections leading to malaria have severe clinical manifestations and high mortality rates. Chloroquine (CQ), a former mainstay of malaria chemotherapy, has been rendered ineffective due to the emergence of widespread...