Jerome Le Nours
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Explore the profile of Jerome Le Nours including associated specialties, affiliations and a list of published articles.
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56
Citations
2457
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Recent Articles
1.
Praveena T, Le Nours J
Front Immunol
. 2025 Mar;
16:1574591.
PMID: 40083544
[This corrects the article DOI: 10.3389/fimmu.2024.1479382.].
2.
Praveena T, Le Nours J
Front Immunol
. 2024 Dec;
15:1479382.
PMID: 39669569
The Natural Killer T cells (NKT) are a unique subset of T lymphocytes that recognize lipid-based antigens that are presented by the monomorphic MHC-I-like molecule, CD1d. Over 30 years ago,...
3.
McInerney M, Awad W, Souter M, Kang Y, Wang C, Chan Yew Poa K, et al.
Proc Natl Acad Sci U S A
. 2024 Nov;
121(49):e2414792121.
PMID: 39589872
The major histocompatibility complex class I related protein (MR1) presents microbially derived vitamin B2 precursors to mucosal-associated invariant T (MAIT) cells. MR1 can also present other metabolites to activate MR1-restricted...
4.
Cornforth T, Moyo N, Cole S, Lam E, Lobry T, Wolchinsky R, et al.
Front Oncol
. 2024 Oct;
14:1419528.
PMID: 39445059
Background: Major histocompatibility complex class-1-related protein (MR1), unlike human leukocyte antigen (HLA) class-1, was until recently considered to be monomorphic. MR1 presents metabolites in the context of host responses to...
5.
Ganley M, Holz L, Minnell J, de Menezes M, Burn O, Chan Yew Poa K, et al.
Nat Immunol
. 2023 Jul;
24(9):1487-1498.
PMID: 37474653
Malaria is caused by Plasmodium species transmitted by Anopheles mosquitoes. Following a mosquito bite, Plasmodium sporozoites migrate from skin to liver, where extensive replication occurs, emerging later as merozoites that...
6.
Wang C, Awad W, Liu L, Mak J, Veerapen N, Illing P, et al.
J Biol Chem
. 2022 Nov;
298(12):102714.
PMID: 36403855
The Major Histocompatibility Complex class I-related protein 1 (MR1) presents small molecule metabolites, drugs, and drug-like molecules that are recognized by MR1-reactive T cells. While we have an understanding of...
7.
Souter M, Awad W, Li S, Pediongco T, Meehan B, Meehan L, et al.
J Exp Med
. 2022 Aug;
219(9).
PMID: 36018322
Mucosal-associated invariant T (MAIT) cells detect microbial infection via recognition of riboflavin-based antigens presented by the major histocompatibility complex class I (MHC-I)-related protein 1 (MR1). Most MAIT cells in human...
8.
Wegrecki M, Ocampo T, Gunasinghe S, von Borstel A, Tin S, Reijneveld J, et al.
Nat Commun
. 2022 Jul;
13(1):3872.
PMID: 35790773
CD1a is a monomorphic antigen-presenting molecule on dendritic cells that presents lipids to αβ T cells. Whether CD1a represents a ligand for other immune receptors remains unknown. Here we use...
9.
Lameris R, Shahine A, Pellicci D, Uldrich A, Gras S, Le Nours J, et al.
Nat Cancer
. 2022 Feb;
1(11):1054-1065.
PMID: 35122066
Antibody-mediated modulation of major histocompatibility complex (MHC) molecules, or MHC class I-like molecules, could constitute an effective immunotherapeutic approach. We describe how single-domain antibodies (VHH), specific for the human MHC...
10.
Oh S, Praveena T, Song H, Yoo J, Jung D, Erturk-Hasdemir D, et al.
Nature
. 2022 Jan;
601(7894):E32.
PMID: 35001086
No abstract available.