Jeremy Leipzig
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Explore the profile of Jeremy Leipzig including associated specialties, affiliations and a list of published articles.
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30
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2765
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Recent Articles
21.
Hoffmann C, Minkah N, Leipzig J, Wang G, Arens M, Tebas P, et al.
Nucleic Acids Res
. 2007 Jun;
35(13):e91.
PMID: 17576693
Treatment of HIV-infected individuals with antiretroviral agents selects for drug-resistant mutants, resulting in frequent treatment failures. Although the major antiretroviral resistance mutations are routinely characterized by DNA sequencing, treatment failures...
22.
Wang G, Ciuffi A, Leipzig J, Berry C, Bushman F
Genome Res
. 2007 Jun;
17(8):1186-94.
PMID: 17545577
Integration of retroviral DNA into host cell DNA is a defining feature of retroviral replication. HIV integration is known to be favored in active transcription units, which promotes efficient transcription...
23.
Berry C, Hannenhalli S, Leipzig J, Bushman F
PLoS Comput Biol
. 2006 Dec;
2(11):e157.
PMID: 17166054
DNA sequences from retroviruses, retrotransposons, DNA transposons, and parvoviruses can all become integrated into the human genome. Accumulation of such sequences accounts for at least 40% of our genome today....
24.
Lewinski M, Yamashita M, Emerman M, Ciuffi A, Marshall H, Crawford G, et al.
PLoS Pathog
. 2006 Jun;
2(6):e60.
PMID: 16789841
Retroviruses differ in their preferences for sites for viral DNA integration in the chromosomes of infected cells. Human immunodeficiency virus (HIV) integrates preferentially within active transcription units, whereas murine leukemia...
25.
Barr S, Ciuffi A, Leipzig J, Shinn P, Ecker J, Bushman F
Mol Ther
. 2006 May;
14(2):218-25.
PMID: 16647883
We have studied the selection of HIV DNA integration sites in primary macrophages to investigate two questions. First, mature macrophages do not divide, allowing us to investigate whether HIV integration...
26.
Ciuffi A, Mitchell R, Hoffmann C, Leipzig J, Shinn P, Ecker J, et al.
Mol Ther
. 2005 Dec;
13(2):366-73.
PMID: 16325473
DNA integration is a defining step in the retroviral life cycle and the basis of stable gene transfer in retrovirus-based gene therapy. Previous studies of integration by HIV-based vectors have...
27.
Ciuffi A, Llano M, Poeschla E, Hoffmann C, Leipzig J, Shinn P, et al.
Nat Med
. 2005 Nov;
11(12):1287-9.
PMID: 16311605
HIV DNA integration is favored in active genes, but the underlying mechanism is unclear. Cellular lens epithelium-derived growth factor (LEDGF/p75) binds both chromosomal DNA and HIV integrase, and might therefore...
28.
Bushman F, Lewinski M, Ciuffi A, Barr S, Leipzig J, Hannenhalli S, et al.
Nat Rev Microbiol
. 2005 Sep;
3(11):848-58.
PMID: 16175173
Retroviral vectors are often used to introduce therapeutic sequences into patients' cells. In recent years, gene therapy with retroviral vectors has had impressive therapeutic successes, but has also resulted in...
29.
Barr S, Leipzig J, Shinn P, Ecker J, Bushman F
J Virol
. 2005 Sep;
79(18):12035-44.
PMID: 16140779
We have analyzed the placement of sites of integration of avian sarcoma-leukosis virus (ASLV) and human immunodeficiency virus (HIV) DNA in the draft chicken genome sequence, with the goals of...
30.
Leipzig J, Pevzner P, Heber S
Nucleic Acids Res
. 2004 Aug;
32(13):3977-83.
PMID: 15292448
Alternative splicing essentially increases the diversity of the transcriptome and has important implications for physiology, development and the genesis of diseases. Conventionally, alternative splicing is investigated in a case-by-case fashion,...