Jeremie Le Pen
Overview
Explore the profile of Jeremie Le Pen including associated specialties, affiliations and a list of published articles.
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Articles
25
Citations
4122
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Recent Articles
1.
Al Qureshah F, Le Pen J, de Weerd N, Moncada-Velez M, Materna M, Lin D, et al.
J Exp Med
. 2024 Dec;
222(2).
PMID: 39680367
Autosomal recessive deficiency of the IFNAR1 or IFNAR2 chain of the human type I IFN receptor abolishes cellular responses to IFN-α, -β, and -ω, underlies severe viral diseases, and is...
2.
Le Pen J, Paniccia G, Kinast V, Moncada-Velez M, Ashbrook A, Bauer M, et al.
PLoS Biol
. 2024 Sep;
22(9):e3002767.
PMID: 39316623
Interferons (IFNs) play a crucial role in the regulation and evolution of host-virus interactions. Here, we conducted a genome-wide arrayed CRISPR knockout screen in the presence and absence of IFN...
3.
Chan Y, Lundberg V, Le Pen J, Yuan J, Lee D, Pinci F, et al.
J Exp Med
. 2024 Jul;
221(9).
PMID: 39023559
Inherited deficiency of the RNA lariat-debranching enzyme 1 (DBR1) is a rare etiology of brainstem viral encephalitis. The cellular basis of disease and the range of viral predisposition are unclear....
4.
Le Pen J, Rice C
Curr Opin Immunol
. 2024 May;
87:102426.
PMID: 38795501
In this review, we provide an overview of the intricate host-virus interactions that have emerged from the study of SARS-CoV-2 infection. We focus on the antiviral mechanisms of interferon-stimulated genes...
5.
Rosain J, Neehus A, Manry J, Yang R, Le Pen J, Daher W, et al.
Cell
. 2023 Feb;
186(3):621-645.e33.
PMID: 36736301
Inborn errors of human IFN-γ-dependent macrophagic immunity underlie mycobacterial diseases, whereas inborn errors of IFN-α/β-dependent intrinsic immunity underlie viral diseases. Both types of IFNs induce the transcription factor IRF1. We...
6.
Lee D, Le Pen J, Yatim A, Dong B, Aquino Y, Ogishi M, et al.
Science
. 2022 Dec;
379(6632):eabo3627.
PMID: 36538032
Multisystem inflammatory syndrome in children (MIS-C) is a rare and severe condition that follows benign COVID-19. We report autosomal recessive deficiencies of , , or in five unrelated children with...
7.
Efstathiou S, Ottens F, Schutter L, Ravanelli S, Charmpilas N, Gutschmidt A, et al.
Nat Cell Biol
. 2022 Dec;
24(12):1714-1725.
PMID: 36471127
The endoplasmic reticulum (ER) coordinates mRNA translation and processing of secreted and endomembrane proteins. ER-associated degradation (ERAD) prevents the accumulation of misfolded proteins in the ER, but the physiological regulation...
8.
Kabbani M, Michailidis E, Steensels S, Fulmer C, Luna J, Le Pen J, et al.
Cell Rep
. 2022 Sep;
40(11):111321.
PMID: 36103835
Advanced non-alcoholic fatty liver disease (NAFLD) is a rapidly emerging global health problem associated with pre-disposing genetic polymorphisms, most strikingly an isoleucine to methionine substitution in patatin-like phospholipase domain-containing protein...
9.
Zhang Q, Matuozzo D, Le Pen J, Lee D, Moens L, Asano T, et al.
J Exp Med
. 2022 Jun;
219(8).
PMID: 35708626
Recessive or dominant inborn errors of type I interferon (IFN) immunity can underlie critical COVID-19 pneumonia in unvaccinated adults. The risk of COVID-19 pneumonia in unvaccinated children, which is much...
10.
Ricardo-Lax I, Luna J, Thao T, Le Pen J, Yu Y, Hoffmann H, et al.
Science
. 2021 Oct;
374(6571):1099-1106.
PMID: 34648371
Molecular virology tools are critical for basic studies of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and for developing new therapeutics. Experimental systems that do not rely on viruses...