Jeremie Le Pen
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Explore the profile of Jeremie Le Pen including associated specialties, affiliations and a list of published articles.
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25
Citations
4122
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Recent Articles
11.
Schneider W, Luna J, Hoffmann H, Sanchez-Rivera F, Leal A, Ashbrook A, et al.
Cell
. 2020 Dec;
184(1):120-132.e14.
PMID: 33382968
The coronavirus disease 2019 (COVID-19) pandemic has claimed the lives of over one million people worldwide. The causative agent, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a member of...
12.
Hoffmann H, Sanchez-Rivera F, Schneider W, Luna J, Soto-Feliciano Y, Ashbrook A, et al.
Cell Host Microbe
. 2020 Dec;
29(2):267-280.e5.
PMID: 33357464
The ongoing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has devastated the global economy and claimed more than 1.7 million lives, presenting an urgent global health crisis. To identify...
13.
Schneider W, Luna J, Hoffmann H, Sanchez-Rivera F, Leal A, Ashbrook A, et al.
bioRxiv
. 2020 Oct;
PMID: 33052332
Highlights: Genome-wide CRISPR screens for SARS-CoV-2, HCoV-OC43, HCoV-NL63, and HCoV-229E coronavirus host factors.Parallel genome-wide CRISPR screening uncovered host factors and pathways with pan-coronavirus and virus-specific functional roles.Coronaviruses co-opt multiple biological...
14.
Bastard P, Rosen L, Zhang Q, Michailidis E, Hoffmann H, Zhang Y, et al.
Science
. 2020 Sep;
370(6515).
PMID: 32972996
Interindividual clinical variability in the course of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is vast. We report that at least 101 of 987 patients with life-threatening coronavirus disease...
15.
Zhang Q, Bastard P, Liu Z, Le Pen J, Moncada-Velez M, Chen J, et al.
Science
. 2020 Sep;
370(6515).
PMID: 32972995
Clinical outcome upon infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ranges from silent infection to lethal coronavirus disease 2019 (COVID-19). We have found an enrichment in rare variants...
16.
Hoffmann H, Schneider W, Sanchez-Rivera F, Luna J, Ashbrook A, Soto-Feliciano Y, et al.
bioRxiv
. 2020 Sep;
PMID: 32935098
Highlights: Focused CRISPR screens targeting host factors in the SARS-CoV-2 interactome were performed for SARS-CoV-2, HCoV-229E, HCoV-NL63, and HCoV-OC43 coronaviruses.Focused interactome CRISPR screens achieve higher resolution compared to genome-wide screens,...
17.
Chauve L, Le Pen J, Hodge F, Todtenhaupt P, Biggins L, Miska E, et al.
J Vis Exp
. 2020 Jun;
(159).
PMID: 32538915
This paper presents a high-throughput reverse transcription quantitative PCR (RT-qPCR) assay for Caenorhabditis elegans that is fast, robust, and highly sensitive. This protocol obtains precise measurements of gene expression from...
18.
Hernandez N, Bucciol G, Moens L, Le Pen J, Shahrooei M, Goudouris E, et al.
J Exp Med
. 2019 Jul;
216(9):2057-2070.
PMID: 31270247
Vaccination against measles, mumps, and rubella (MMR) and yellow fever (YF) with live attenuated viruses can rarely cause life-threatening disease. Severe illness by MMR vaccines can be caused by inborn...
19.
20.
Le Pen J, Jiang H, Di Domenico T, Kneuss E, Kosalka J, Leung C, et al.
Nat Struct Mol Biol
. 2018 Aug;
25(9):778-786.
PMID: 30104661
RNA viruses are a major threat to animals and plants. RNA interference (RNAi) and the interferon response provide innate antiviral defense against RNA viruses. Here, we performed a large-scale screen...