Jerard Hurwitz
Overview
Explore the profile of Jerard Hurwitz including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
61
Citations
2810
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Cottineau J, Kottemann M, Lach F, Kang Y, Vely F, Deenick E, et al.
J Clin Invest
. 2017 Apr;
127(5):1991-2006.
PMID: 28414293
Inborn errors of DNA repair or replication underlie a variety of clinical phenotypes. We studied 5 patients from 4 kindreds, all of whom displayed intrauterine growth retardation, chronic neutropenia, and...
2.
Wu K, Chong R, Yu Q, Bai J, Spratt D, Ching K, et al.
Proc Natl Acad Sci U S A
. 2016 Mar;
113(14):E2011-8.
PMID: 27001857
Cullin-RING E3 ubiquitin ligases (CRL) control a myriad of biological processes by directing numerous protein substrates for proteasomal degradation. Key to CRL activity is the recruitment of the E2 ubiquitin-conjugating...
3.
Campos E, Smits A, Kang Y, Landry S, Escobar T, Nayak S, et al.
Mol Cell
. 2015 Nov;
60(4):697-709.
PMID: 26527279
Despite minimal disparity at the sequence level, mammalian H3 variants bind to distinct sets of polypeptides. Although histone H3.1 predominates in cycling cells, our knowledge of the soluble complexes that...
4.
Im J, Park S, Cho W, Bae S, Hurwitz J, Lee J
Cell Cycle
. 2015 Jan;
14(7):1001-9.
PMID: 25602958
Though RecQL4 was shown to be essential for the initiation of DNA replication in mammalian cells, its role in initiation is poorly understood. Here, we show that RecQL4 is required...
5.
Lue N, Chan J, Wright W, Hurwitz J
Nat Commun
. 2014 Dec;
5:5762.
PMID: 25503194
Emerging evidence suggests that Cdc13-Stn1-Ten1 (CST), an RPA-like ssDNA-binding complex, may regulate primase-Pol α (PP) activity at telomeres constitutively, and at other genomic locations under conditions of replication stress. Here...
6.
Chong R, Wu K, Spratt D, Yang Y, Lee C, Nayak J, et al.
Proc Natl Acad Sci U S A
. 2014 Jun;
111(23):8434-9.
PMID: 24912152
Lysine 48 (K48)-polyubiquitination is the predominant mechanism for mediating selective protein degradation, but the underlying molecular basis of selecting ubiquitin (Ub) K48 for linkage-specific chain synthesis remains elusive. Here, we...
7.
Li Z, Huang R, Yopp D, Hileman T, Santangelo T, Hurwitz J, et al.
Nucleic Acids Res
. 2014 Apr;
42(9):5776-89.
PMID: 24728986
Proliferating cell nuclear antigen (PCNA) forms a trimeric ring that associates with and influences the activity of many proteins participating in DNA metabolic processes and cell cycle progression. Previously, an...
8.
Hartmann T, Xu X, Kronast M, Muehlich S, Meyer K, Zimmermann W, et al.
Proc Natl Acad Sci U S A
. 2014 Feb;
111(9):3371-6.
PMID: 24550499
Simian virus 40 (SV40) large tumor antigen (LT) triggers oncogenic transformation by inhibition of key tumor suppressor proteins, including p53 and members of the retinoblastoma family. In addition, SV40 transformation...
9.
Kang Y, Farina A, Bermudez V, Tappin I, Du F, Galal W, et al.
Proc Natl Acad Sci U S A
. 2013 Nov;
110(49):19760-5.
PMID: 24255107
Chromosome transmission fidelity 4 (Ctf4) is a conserved protein required for DNA replication. In this report, interactions between human Ctf4 (hCtf4) and the replicative helicase containing the cell division cycle...
10.
Sneeden J, Grossi S, Tappin I, Hurwitz J, Heyer W
Nucleic Acids Res
. 2013 Mar;
41(9):4913-25.
PMID: 23535143
The repair of DNA breaks by homologous recombination is a high-fidelity process, necessary for the maintenance of genome integrity. Thus, DNA synthesis associated with recombinational repair must be largely error-free....