Louise Prakash
Overview
Explore the profile of Louise Prakash including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
121
Citations
5695
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Malik R, Johnson R, Ubarretxena-Belandia I, Prakash L, Prakash S, Aggarwal A
Nat Struct Mol Biol
. 2024 May;
31(9):1394-1403.
PMID: 38720088
Rev1-Polζ-dependent translesion synthesis (TLS) of DNA is crucial for maintaining genome integrity. To elucidate the mechanism by which the two polymerases cooperate in TLS, we determined the cryogenic electron microscopic...
2.
Yoon J, Sellamuthu K, Prakash L, Prakash S
Genes Dev
. 2024 Mar;
38(5-6):213-232.
PMID: 38503516
Purified translesion synthesis (TLS) DNA polymerases (Pols) replicate through DNA lesions with a low fidelity; however, TLS operates in a predominantly error-free manner in normal human cells. To explain this...
3.
DNA polymerase ε leading strand signature mutations result from defects in its proofreading activity
Johnson R, Prakash L, Prakash S
J Biol Chem
. 2023 Jun;
299(7):104913.
PMID: 37307920
The evidence that purified pol2-M644G DNA polymerase (Pol)ε exhibits a highly elevated bias for forming T:dTTP mispairs over A:dATP mispairs and that yeast cells harboring this Polε mutation accumulate A...
4.
Klassen R, Gangavarapu V, Johnson R, Prakash L, Prakash S
J Biol Chem
. 2023 Mar;
299(4):104598.
PMID: 36898578
DNA mismatch repair (MMR) in eukaryotes is believed to occur post-replicatively, wherein nicks or gaps in the nascent DNA strand are suggested to serve as strand discrimination signals. However, how...
5.
Acharya N, Prakash L, Prakash S
J Biol Chem
. 2022 Nov;
299(1):102727.
PMID: 36410434
Eukaryotic cells harbor two DNA-binding clamps, proliferating cell nuclear antigen (PCNA), and another clamp commonly referred to as 9-1-1 clamp. In contrast to the essential role of PCNA in DNA...
6.
Malik R, Johnson R, Prakash L, Prakash S, Ubarretxena-Belandia I, Aggarwal A
Nat Commun
. 2022 Feb;
13(1):1050.
PMID: 35217661
The B-family multi-subunit DNA polymerase ζ (Polζ) is important for translesion DNA synthesis (TLS) during replication, due to its ability to extend synthesis past nucleotides opposite DNA lesions and mismatched...
7.
Yoon J, Johnson R, Prakash L, Prakash S
Genes Dev
. 2021 Aug;
35(17-18):1256-1270.
PMID: 34385260
Chemotherapy with cisplatin becomes limiting due to toxicity and secondary malignancies. In principle, therapeutics could be improved by targeting translesion synthesis (TLS) polymerases (Pols) that promote replication through intrastrand cross-links,...
8.
Rechkoblit O, Johnson R, Gupta Y, Prakash L, Prakash S, Aggarwal A
Nat Commun
. 2021 Jun;
12(1):4020.
PMID: 34188055
PrimPol is a human DNA polymerase-primase that localizes to mitochondria and nucleus and bypasses the major oxidative lesion 7,8-dihydro-8-oxoguanine (oxoG) via translesion synthesis, in mostly error-free manner. We present structures...
9.
Yoon J, Basu D, Choudhury J, Prakash S, Prakash L
J Biol Chem
. 2021 Jun;
297(1):100868.
PMID: 34119520
In a previous study, we showed that replication through the N1-methyl-deoxyadenosine (1-MeA) adduct in human cells is mediated via three different Polι/Polθ, Polη, and Polζ-dependent pathways. Based on biochemical studies...
10.
Yoon J, Basu D, Sellamuthu K, Johnson R, Prakash S, Prakash L
Life Sci Alliance
. 2021 Jan;
4(4).
PMID: 33514655
By extending synthesis opposite from a diverse array of DNA lesions, DNA polymerase (Pol) ζ performs a crucial role in translesion synthesis (TLS). In yeast and cancer cells, Rev1 functions...