Jerard Hurwitz
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Explore the profile of Jerard Hurwitz including associated specialties, affiliations and a list of published articles.
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61
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Recent Articles
11.
Pan M, Santangelo T, Cubonova L, Li Z, Metangmo H, Ladner J, et al.
Extremophiles
. 2013 Mar;
17(3):453-61.
PMID: 23525944
Proliferating cell nuclear antigen (PCNA) monomers assemble to form a ring-shaped clamp complex that encircles duplex DNA. PCNA binding to other proteins tethers them to the DNA providing contacts and...
12.
Cho W, Kang Y, An Y, Tappin I, Hurwitz J, Lee J
Proc Natl Acad Sci U S A
. 2013 Jan;
110(7):2523-7.
PMID: 23359676
Tim (Timeless) and Tipin (Tim-interacting protein) form a stable heterodimeric complex that influences checkpoint responses and replication fork progression. We report that the Tim-Tipin complex interacts with essential replication fork...
13.
Yardimci H, Wang X, Loveland A, Tappin I, Rudner D, Hurwitz J, et al.
Nature
. 2012 Dec;
492(7428):205-9.
PMID: 23201686
Replicative DNA helicases generally unwind DNA as a single hexamer that encircles and translocates along one strand of the duplex while excluding the complementary strand (known as steric exclusion). By...
14.
Galal W, Kang Y, Hurwitz J
Cell Cycle
. 2012 Jul;
11(15):2771-2.
PMID: 22833048
No abstract available.
15.
Bermudez V, Farina A, Higashi T, Du F, Tappin I, Takahashi T, et al.
Proc Natl Acad Sci U S A
. 2012 May;
109(24):9366-71.
PMID: 22628566
The loading of cohesin onto chromatin requires the heterodimeric complex sister chromatid cohesion (Scc)2 and Scc4 (Scc2/4), which is highly conserved in all species. Here, we describe the purification of...
16.
Kang Y, Galal W, Farina A, Tappin I, Hurwitz J
Proc Natl Acad Sci U S A
. 2012 Apr;
109(16):6042-7.
PMID: 22474384
In eukaryotes, although the Mcm2-7 complex is a key component of the replicative DNA helicase, its association with Cdc45 and GINS (the CMG complex) is required for the activation of...
17.
Galal W, Pan M, Giulian G, Yuan W, Li S, Edwards J, et al.
J Biol Chem
. 2012 Mar;
287(20):16220-9.
PMID: 22427647
In the presence of dATP, glycerol, and Tris buffer, the DNA primase isolated from Thermococcus kodakaraensis catalyzed the formation of dAMP and two products that were identified as dAMP-glycerol and...
18.
Galal W, Pan M, Kelman Z, Hurwitz J
J Biol Chem
. 2012 Feb;
287(20):16209-19.
PMID: 22351771
In most organisms, DNA replication is initiated by DNA primases, which synthesize primers that are elongated by DNA polymerases. In this study, we describe the isolation and biochemical characterization of...
19.
Fu Y, Yardimci H, Long D, Ho T, Guainazzi A, Bermudez V, et al.
Cell
. 2011 Sep;
146(6):931-41.
PMID: 21925316
The eukaryotic replicative DNA helicase, CMG, unwinds DNA by an unknown mechanism. In some models, CMG encircles and translocates along one strand of DNA while excluding the other strand. In...
20.
Bermudez V, Farina A, Raghavan V, Tappin I, Hurwitz J
J Biol Chem
. 2011 Jun;
286(33):28963-28977.
PMID: 21705323
In eukaryotic cells, DNA replication is carried out by the coordinated action of three DNA polymerases (Pols), Pol α, δ, and ε. In this report, we describe the reconstitution of...