Jennifer Fishovitz
Overview
Explore the profile of Jennifer Fishovitz including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
20
Citations
421
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Sha Z, Fishovitz J, Wang S, Chilakala S, Xu Y, Lee I
Chembiochem
. 2020 Mar;
21(14):2037-2048.
PMID: 32180333
The goal of this work is to identify differences in the substrate determinants of two human mitochondrial matrix ATP-dependent proteases, human ClpXP (hClpXP) and human Lon (hLon). This information allows...
2.
Sha Z, Chilakala S, Crabill G, Cheng I, Xu Y, Fishovitz J, et al.
Chembiochem
. 2020 Mar;
21(14):2049-2059.
PMID: 32180302
Human caseinolytic protease component X and P (hClpXP) is a heterooligomeric ATP-dependent protease. The hClpX subunit catalyzes ATP hydrolysis whereas the hClpP subunit catalyzes peptide bond cleavage. In this study,...
3.
Speri E, Kim C, De Benedetti S, Qian Y, Lastochkin E, Fishovitz J, et al.
ACS Med Chem Lett
. 2019 Aug;
10(8):1148-1153.
PMID: 31413798
β-Lactams are used routinely to treat infections. However, the emergence of methicillin-resistant (MRSA) renders them clinically precarious. We describe a class of cinnamonitrile adjuvants that restore the activity of oxacillin...
4.
Speri E, Fishovitz J, Mobashery S
Medchemcomm
. 2019 Feb;
9(12):2008-2016.
PMID: 30746061
Methicillin-resistant (MRSA) is a global public health threat. MRSA has evolved a complex set of biochemical processes that mobilize the organism for inducible resistance on challenge by β-lactam antibiotics. Interfering...
5.
Fishovitz J, Sha Z, Chilakala S, Cheng I, Xu Y, Lee I
Front Mol Biosci
. 2017 Jul;
4:47.
PMID: 28744459
Lon, also known as Protease La, is one of the simplest ATP-dependent proteases. It is a homooligomeric enzyme comprised of an ATPase domain and a proteolytic domain in each enzyme...
6.
Lee M, Hesek D, Dik D, Fishovitz J, Lastochkin E, Boggess B, et al.
Angew Chem Int Ed Engl
. 2017 Jan;
56(10):2735-2739.
PMID: 28128504
An enzyme superfamily, the lytic transglycosylases (LTs), occupies the space between the two membranes of Gram-negative bacteria. LTs catalyze the non-hydrolytic cleavage of the bacterial peptidoglycan cell-wall polymer. This reaction...
7.
Dik D, Dominguez-Gil T, Lee M, Hesek D, Byun B, Fishovitz J, et al.
J Am Chem Soc
. 2017 Jan;
139(4):1448-1451.
PMID: 28079369
A complex link exists between cell-wall recycling/repair and the manifestation of resistance to β-lactam antibiotics in many Enterobacteriaceae and Pseudomonas aeruginosa. This process is mediated by specific cell-wall-derived muropeptide products....
8.
Boudreau M, Fishovitz J, Llarrull L, Xiao Q, Mobashery S
ACS Infect Dis
. 2016 Sep;
1(10):454-9.
PMID: 27623311
Methicillin-resistant Staphylococcus aureus (MRSA), an important human pathogen, has evolved an inducible mechanism for resistance to β-lactam antibiotics. We report herein that the integral membrane protein BlaR1, the β-lactam sensor/signal...
9.
Galimand M, Fishovitz J, Lambert T, Barbe V, Zajicek J, Mobashery S, et al.
Antimicrob Agents Chemother
. 2015 Jul;
59(9):5647-53.
PMID: 26149994
Corynebacterium striatum BM4687 was resistant to gentamicin and tobramycin but susceptible to kanamycin A and amikacin, a phenotype distinct among Gram-positive bacteria. Analysis of the entire genome of this strain...
10.
Fishovitz J, Taghizadeh N, Fisher J, Chang M, Mobashery S
J Am Chem Soc
. 2015 May;
137(20):6500-5.
PMID: 25964995
The transpeptidases involved in the synthesis of the bacterial cell wall (also known as penicillin-binding proteins, PBPs) have evolved to bind the acyl-D-Ala-D-Ala segment of the stem peptide of the...