Sujatha Chilakala
Overview
Explore the profile of Sujatha Chilakala including associated specialties, affiliations and a list of published articles.
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Articles
11
Citations
142
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Recent Articles
1.
Abdel-Haq R, Schlachetzki J, Boktor J, Cantu-Jungles T, Thron T, Zhang M, et al.
Elife
. 2023 Aug;
12.
PMID: 37650862
No abstract available.
2.
Abdel-Haq R, Schlachetzki J, Boktor J, Cantu-Jungles T, Thron T, Zhang M, et al.
Elife
. 2022 Nov;
11.
PMID: 36346385
Parkinson's disease (PD) is a movement disorder characterized by neuroinflammation, α-synuclein pathology, and neurodegeneration. Most cases of PD are non-hereditary, suggesting a strong role for environmental factors, and it has...
3.
Strelez C, Chilakala S, Ghaffarian K, Lau R, Spiller E, Ung N, et al.
iScience
. 2021 Jun;
24(5):102509.
PMID: 34113836
Colorectal cancer (CRC) progression is a complex process that is not well understood. We describe an organ-on-chip model that emulates tissue structure and the tumor microenvironment (TME) to better understand...
4.
Sha Z, Fishovitz J, Wang S, Chilakala S, Xu Y, Lee I
Chembiochem
. 2020 Mar;
21(14):2037-2048.
PMID: 32180333
The goal of this work is to identify differences in the substrate determinants of two human mitochondrial matrix ATP-dependent proteases, human ClpXP (hClpXP) and human Lon (hLon). This information allows...
5.
Sha Z, Chilakala S, Crabill G, Cheng I, Xu Y, Fishovitz J, et al.
Chembiochem
. 2020 Mar;
21(14):2049-2059.
PMID: 32180302
Human caseinolytic protease component X and P (hClpXP) is a heterooligomeric ATP-dependent protease. The hClpX subunit catalyzes ATP hydrolysis whereas the hClpP subunit catalyzes peptide bond cleavage. In this study,...
6.
Chilakala S, Feng Y, Li L, Mahfouz R, Quteba E, Saunthararajah Y, et al.
Sci Rep
. 2019 Mar;
9(1):4558.
PMID: 30872721
The DNA hypomethylating agents decitabine and 5-azacytidine are the only two drugs approved for treatment of all subtypes of the myeloid malignancy myelodysplastic syndromes (MDS). The key to drug activity...
7.
Chilakala S, Cheng I, Lee I, Xu Y
Anal Biochem
. 2018 Nov;
566:62-66.
PMID: 30419188
A method is proposed in this paper for the determination of oxygen-18 labeled phosphate so that positional isotope experiments using sensitive and rapid liquid chromatography-QTOF-mass spectrometry (LC-QTOF-MS) experiments can be...
8.
Chilakala S, Li L, Feng Y, Xu Y
Anal Biochem
. 2018 Feb;
546:28-34.
PMID: 29408176
Study of DNA base composition, DNA adducts and modification in its primary structure is a subject of interest in different fields of scientific research. Various methods like immunochemistry, capillary electrophoretic...
9.
Fishovitz J, Sha Z, Chilakala S, Cheng I, Xu Y, Lee I
Front Mol Biosci
. 2017 Jul;
4:47.
PMID: 28744459
Lon, also known as Protease La, is one of the simplest ATP-dependent proteases. It is a homooligomeric enzyme comprised of an ATPase domain and a proteolytic domain in each enzyme...
10.
Vatolin S, Phillips J, Jha B, Govindgari S, Hu J, Grabowski D, et al.
Cancer Res
. 2016 May;
76(11):3340-50.
PMID: 27197150
Multiple myeloma cells secrete more disulfide bond-rich proteins than any other mammalian cell. Thus, inhibition of protein disulfide isomerases (PDI) required for protein folding in the endoplasmic reticulum (ER) should...