Jed F Fisher
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Explore the profile of Jed F Fisher including associated specialties, affiliations and a list of published articles.
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72
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2216
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Recent Articles
1.
El-Araby A, Fisher J, Mobashery S
Curr Opin Chem Biol
. 2024 Dec;
84:102562.
PMID: 39700530
The peptidoglycan manifests as a multifaceted component of the bacterial cell wall. Throughout the lifecycle of the bacterium, the peptidoglycan is deconstructed, rebuilt, and remodeled for bacterial cell growth and...
2.
Nguyen V, Birhanu B, Miguel-Ruano V, Kim C, Batuecas M, Yang J, et al.
Nat Chem Biol
. 2024 Jul;
PMID: 39060390
Infections by Staphylococcus aureus have been treated historically with β-lactam antibiotics. However, these antibiotics have become obsolete in methicillin-resistant S. aureus by acquisition of the bla and mec operons. The...
3.
Avila-Cobian L, De Benedetti S, Hoshino H, Nguyen V, El-Araby A, Sader S, et al.
Protein Sci
. 2024 Jun;
33(7):e5038.
PMID: 38864725
Peptidoglycan is a major constituent of the bacterial cell wall. Its integrity as a polymeric edifice is critical for bacterial survival and, as such, it is a preeminent target for...
4.
Avila-Cobian L, Hoshino H, Horsman M, Nguyen V, Qian Y, Feltzer R, et al.
Protein Sci
. 2023 Sep;
32(10):e4781.
PMID: 37703013
The 11 lytic transglycosylases of Pseudomonas aeruginosa have overlapping activities in the turnover of the cell-wall peptidoglycan. Rare lipoprotein A (RlpA) is distinct among the 11 by its use of...
5.
El-Araby A, Jimenez-Faraco E, Feltzer R, Martin-Garcia J, Karri B, Ramachandran B, et al.
J Biol Chem
. 2023 Sep;
299(10):105198.
PMID: 37660917
The bacterial cell envelope is the structure with which the bacterium engages with, and is protected from, its environment. Within this envelop is a conserved peptidoglycan polymer which confers shape...
6.
Fisher J, Mobashery S
Mar Drugs
. 2023 Feb;
21(2).
PMID: 36827127
The title of this essay is as much a question as it is a statement. The discovery of the β-lactam antibiotics-including penicillins, cephalosporins, and carbapenems-as largely (if not exclusively) secondary...
7.
Avila-Cobian L, De Benedetti S, Kim C, Feltzer R, Champion M, Fisher J, et al.
Commun Biol
. 2022 Nov;
5(1):1314.
PMID: 36451021
The protein networks of cell-wall-biosynthesis assemblies are largely unknown. A key class of enzymes in these assemblies is the lytic transglycosylases (LTs), of which eleven exist in P. aeruginosa. We...
8.
Martinez-Caballero S, Mahasenan K, Kim C, Molina R, Feltzer R, Lee M, et al.
Comput Struct Biotechnol J
. 2021 Oct;
19:5392-5405.
PMID: 34667534
The penicillin-binding proteins are the enzyme catalysts of the critical transpeptidation crosslinking polymerization reaction of bacterial peptidoglycan synthesis and the molecular targets of the penicillin antibiotics. Here, we report a...
9.
Gabriel C, Nguyen T, Gargano E, Fisher J, Chang M, Mobashery S
ACS Pharmacol Transl Sci
. 2021 Jun;
4(3):1204-1213.
PMID: 34151210
()-ND-336-designated as compound ()--is a highly selective inhibitor of matrix metalloproteinase (MMP)-9 with efficacy in accelerating diabetic wound healing in murine models. ()-ND-336 belongs to the class of thiirane inhibitors...
10.
Speri E, Qian Y, Janardhanan J, Masitas C, Lastochkin E, De Benedetti S, et al.
ACS Med Chem Lett
. 2021 Jun;
12(6):991-995.
PMID: 34141083
is a leading health threat. This pathogen initiates intestinal infections during gut microbiota dysbiosis caused by oral administration of antibiotics. is difficult to eradicate due to its ability to form...