Jehad Almaliti
Overview
Explore the profile of Jehad Almaliti including associated specialties, affiliations and a list of published articles.
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Articles
32
Citations
1999
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0
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Recent Articles
1.
Bou Malhab L, Harb A, Eldohaji L, Taneera J, Al-Hroub H, Abuhelwa A, et al.
Food Sci Nutr
. 2025 Jan;
13(1):e4715.
PMID: 39803277
Colorectal cancer (CRC) is a prevalent and deadly disease, necessitating the exploration of novel therapeutic strategies. Traditional chemotherapy often encounters drug resistance and adverse side effects, highlighting the need for...
2.
Liu L, Francisco K, Sun Y, Serafim M, Amarasinghe D, Teixeira T, et al.
ACS Infect Dis
. 2024 Nov;
10(12):4182-4193.
PMID: 39589805
The proteasome is essential for eukaryotic cell proteostasis, and inhibitors of the 20S proteasome are progressing preclinically and clinically as antiparasitics. We screened, the causative agent of human and animal...
3.
Fajtova P, Hurysz B, Miyamoto Y, Serafim M, Jiang Z, Vazquez J, et al.
Protein Sci
. 2024 Nov;
33(12):e5225.
PMID: 39589076
The protozoan parasite Trichomonas vaginalis (Tv) causes trichomoniasis, the most common non-viral sexually transmitted infection in the world. Although Tv has been linked to significant health complications, only two closely...
4.
Robbertse L, Fajtova P, Snebergerova P, Jalovecka M, Levytska V, Barbosa da Silva E, et al.
ACS Omega
. 2024 Nov;
9(45):44989-44999.
PMID: 39554424
Tick-transmitted are a major global veterinary threat and an emerging risk to humans. Unlike their relatives, these erythrocyte-infecting Apicomplexa have been largely overlooked and lack specific treatment. Selective targeting of...
5.
Silhan J, Fajtova P, Bartosova J, Hurysz B, Almaliti J, Miyamoto Y, et al.
Nat Commun
. 2024 Oct;
15(1):8621.
PMID: 39366995
The proteasome is a proteolytic enzyme complex essential for protein homeostasis in mammalian cells and protozoan parasites like Trichomonas vaginalis (Tv), the cause of the most common, non-viral sexually transmitted...
6.
Spiwokova P, Horn M, Fanfrlik J, Jilkova A, Fajtova P, Leontovyc A, et al.
ACS Infect Dis
. 2024 May;
10(6):1935-1948.
PMID: 38757505
Schistosomiasis, caused by a parasitic blood fluke of the genus is a global health problem for which new chemotherapeutic options are needed. We explored the scaffold of gallinamide A, a...
7.
Almaliti J, Alhindy M, Yoon M, Hook V, Molinski T, ODonoghue A, et al.
ACS Omega
. 2024 Jan;
9(3):3997-4003.
PMID: 38284081
Protecting groups (PGs) in peptide synthesis have inspired advanced design principles that incorporate "orthogonality" for selective C- and N-terminus and side-chain deprotections. The conventionally acid-stable 9-fluorenylmethoxycarbonyl (Fmoc) group is one...
8.
Bennett J, Ward K, Muir R, Kabeche S, Yoo E, Yeo T, et al.
ACS Infect Dis
. 2023 Sep;
9(10):2036-2047.
PMID: 37712594
The proteasome is a promising antimalarial drug target due to its essential role in all parasite lifecycle stages. Furthermore, proteasome inhibitors have synergistic effects when combined with current first-line artemisinin...
9.
Silhan J, Fajtova P, Bartosova J, Hurysz B, Almaliti J, Miyamoto Y, et al.
bioRxiv
. 2023 Aug;
PMID: 37645851
Proteasomes are essential for protein homeostasis in mammalian cells and in protozoan parasites such as . and other protozoan 20S proteasomes have been validated as druggable targets. However, in the...
10.
Al-Sulaiti H, Almaliti J, Naman C, Al Thani A, Yassine H
Metabolites
. 2023 Aug;
13(8).
PMID: 37623891
Metabolomics is an analytical approach that involves profiling and comparing the metabolites present in biological samples. This scoping review article offers an overview of current metabolomics approaches and their utilization...