Lars Eckmann
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Explore the profile of Lars Eckmann including associated specialties, affiliations and a list of published articles.
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Articles
158
Citations
10659
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Recent Articles
1.
Spalinger M, Sanati G, Chatterjee P, Hai R, Li J, Santos A, et al.
Cell Mol Gastroenterol Hepatol
. 2025 Jan;
19(5):101447.
PMID: 39756517
Background & Aims: Coronavirus disease (COVID-19), caused by severe acquired respiratory syndrome-Coronavirus-2 (SARS-CoV-2), triggered a global pandemic with severe medical and socioeconomic consequences. Although fatality rates are higher among the...
2.
Fajtova P, Hurysz B, Miyamoto Y, Serafim M, Jiang Z, Vazquez J, et al.
Protein Sci
. 2024 Nov;
33(12):e5225.
PMID: 39589076
The protozoan parasite Trichomonas vaginalis (Tv) causes trichomoniasis, the most common non-viral sexually transmitted infection in the world. Although Tv has been linked to significant health complications, only two closely...
3.
Chatterjee P, Spalinger M, Acevedo C, Gries C, Manz S, Canale V, et al.
bioRxiv
. 2024 Oct;
PMID: 39386684
Background And Aims: Loss of activity of the inflammatory bowel disease (IBD) susceptibility gene, protein tyrosine phosphatase non-receptor type 2 (), is associated with altered microbiome composition in both human...
4.
Silhan J, Fajtova P, Bartosova J, Hurysz B, Almaliti J, Miyamoto Y, et al.
Nat Commun
. 2024 Oct;
15(1):8621.
PMID: 39366995
The proteasome is a proteolytic enzyme complex essential for protein homeostasis in mammalian cells and protozoan parasites like Trichomonas vaginalis (Tv), the cause of the most common, non-viral sexually transmitted...
5.
Nieskens N, Miyamoto Y, Hurysz B, ODonoghue A, Eckmann L
PLoS One
. 2024 Oct;
19(10):e0308672.
PMID: 39352907
Trichomonas vaginalis is the causative agent of the common sexually transmitted disease, trichomoniasis, which affects more than a hundred million people worldwide. Metronidazole and tinidazole, agents belonging to the 5-nitroheterocyclic...
6.
Sajek M, Bilodeau D, Beer M, Horton E, Miyamoto Y, Velle K, et al.
Genome Res
. 2024 Sep;
34(10):1570-1581.
PMID: 39327029
The poly(A) signal, together with auxiliary elements, directs cleavage of a pre-mRNA and thus determines the 3' end of the mature transcript. In many species, including humans, the poly(A) signal...
7.
Ihara S, Nguyen B, Miyamoto Y, Eckmann L
Infect Immun
. 2024 May;
92(6):e0006524.
PMID: 38722167
is an important protozoan cause of diarrheal disease worldwide, delayed development and cognitive impairment in children in low- and middle-income countries, and protracted post-infectious syndromes in developed regions. resides in...
8.
Escrig J, Miyamoto Y, Aznar A, Eckmann L, Debnath A
Antimicrob Agents Chemother
. 2023 Dec;
68(1):e0073123.
PMID: 38063401
The intestinal parasites and are major causes of morbidity and mortality associated with diarrheal diseases. Metronidazole is the most common drug used to treat giardiasis and amebiasis. Despite its efficacy,...
9.
Silhan J, Fajtova P, Bartosova J, Hurysz B, Almaliti J, Miyamoto Y, et al.
bioRxiv
. 2023 Aug;
PMID: 37645851
Proteasomes are essential for protein homeostasis in mammalian cells and in protozoan parasites such as . and other protozoan 20S proteasomes have been validated as druggable targets. However, in the...
10.
Zeng L, Herdman D, Lee S, Tao A, Das M, Bertin S, et al.
Diabetes
. 2023 May;
72(9):1235-1250.
PMID: 37257047
Article Highlights: We undertook this study to understand how immune cells communicate with adipocytes, specifically, whether cAMP signaling in the immune cell and the adipocyte are connected. We identified a...