Jeffrey J Quinn
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Explore the profile of Jeffrey J Quinn including associated specialties, affiliations and a list of published articles.
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13
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2724
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Recent Articles
1.
Li J, Xu S, Liu Z, Yang L, Ming Z, Zhang R, et al.
Nat Commun
. 2025 Jan;
16(1):155.
PMID: 39747148
Long noncoding RNAs known as roX (RNA on the X) are crucial for male development in Drosophila, as their loss leads to male lethality from the late larval stages. While...
2.
Arnaoutova I, Aratyn-Schaus Y, Zhang L, Packer M, Chen H, Lee C, et al.
Nat Commun
. 2024 Nov;
15(1):9729.
PMID: 39523369
Glycogen storage disease type-Ia patients, deficient in the G6PC1 gene encoding glucose-6-phosphatase-α, lack blood glucose control, resulting in life-threatening hypoglycemia. Here we show our humanized mouse model, huR83C, carrying the...
3.
Yang D, Jones M, Naranjo S, Rideout 3rd W, Min K, Ho R, et al.
Cell
. 2022 May;
185(11):1905-1923.e25.
PMID: 35523183
Tumor evolution is driven by the progressive acquisition of genetic and epigenetic alterations that enable uncontrolled growth and expansion to neighboring and distal tissues. The study of phylogenetic relationships between...
4.
Quinn J, Jones M, Okimoto R, Nanjo S, Chan M, Yosef N, et al.
Science
. 2021 Jan;
371(6532).
PMID: 33479121
Detailed phylogenies of tumor populations can recount the history and chronology of critical events during cancer progression, such as metastatic dissemination. We applied a Cas9-based, single-cell lineage tracer to study...
5.
Jones M, Khodaverdian A, Quinn J, Chan M, Hussmann J, Wang R, et al.
Genome Biol
. 2020 Apr;
21(1):92.
PMID: 32290857
The pairing of CRISPR/Cas9-based gene editing with massively parallel single-cell readouts now enables large-scale lineage tracing. However, the rapid growth in complexity of data from these assays has outpaced our...
6.
Chan M, Smith Z, Grosswendt S, Kretzmer H, Norman T, Adamson B, et al.
Nature
. 2019 May;
570(7759):77-82.
PMID: 31086336
Ontogeny describes the emergence of complex multicellular organisms from single totipotent cells. This field is particularly challenging in mammals, owing to the indeterminate relationship between self-renewal and differentiation, variation in...
7.
Quinn J, Zhang Q, Georgiev P, Ilik I, Akhtar A, Chang H
Genes Dev
. 2016 Jan;
30(2):191-207.
PMID: 26773003
Many long noncoding RNAs (lncRNAs) can regulate chromatin states, but the evolutionary origin and dynamics driving lncRNA-genome interactions are unclear. We adapted an integrative strategy that identifies lncRNA orthologs in...
8.
Quinn J, Chang H
Nat Rev Genet
. 2015 Dec;
17(1):47-62.
PMID: 26666209
Long non-coding RNAs (lncRNAs) are a diverse class of RNAs that engage in numerous biological processes across every branch of life. Although initially discovered as mRNA-like transcripts that do not...
9.
Carlson H, Quinn J, Yang Y, Thornburg C, Chang H, Stadler H
PLoS Genet
. 2015 Dec;
11(12):e1005680.
PMID: 26633036
Gene expression profiling in E 11 mouse embryos identified high expression of the long noncoding RNA (lncRNA), LNCRNA-HIT in the undifferentiated limb mesenchyme, gut, and developing genital tubercle. In the...
10.
Quinn J, Chang H
Methods Mol Biol
. 2015 Jan;
1262:199-213.
PMID: 25555583
Here we describe domain-specific chromatin isolation by RNA purification (dChIRP), a technique for dissecting the functional domains of a target RNA in situ. For an RNA of interest, dChIRP can...