Jeff E Mold
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Explore the profile of Jeff E Mold including associated specialties, affiliations and a list of published articles.
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31
Citations
1766
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Recent Articles
1.
Rodahl I, Ivarsson M, Loh L, Mold J, Westgren M, Friberg D, et al.
Eur J Immunol
. 2024 Dec;
55(2):e202451150.
PMID: 39676343
The human fetal immune system starts to develop in the first trimester and likely plays a crucial role in fetal development and maternal-fetal tolerance. Innate lymphoid cells (ILCs) are the...
2.
Shafighi S, Geras A, Jurzysta B, Sahaf Naeini A, Filipiuk I, Raczkowska A, et al.
Nat Commun
. 2024 Oct;
15(1):9343.
PMID: 39472583
Spatial and genomic heterogeneity of tumors are crucial factors influencing cancer progression, treatment, and survival. However, a technology for direct mapping the clones in the tumor tissue based on somatic...
3.
Mold J, Weissman M, Ratz M, Hagemann-Jensen M, Hard J, Eriksson C, et al.
Cell Syst
. 2024 Feb;
15(2):149-165.e10.
PMID: 38340731
Cell types can be classified according to shared patterns of transcription. Non-genetic variability among individual cells of the same type has been ascribed to stochastic transcriptional bursting and transient cell...
4.
Engblom C, Thrane K, Lin Q, Andersson A, Toosi H, Chen X, et al.
Science
. 2023 Dec;
382(6675):eadf8486.
PMID: 38060664
The spatial distribution of lymphocyte clones within tissues is critical to their development, selection, and expansion. We have developed spatial transcriptomics of variable, diversity, and joining (VDJ) sequences (Spatial VDJ),...
5.
Sorini C, Cardoso R, Tripathi K, Mold J, Diaz O, Holender Y, et al.
Mucosal Immunol
. 2023 Nov;
17(1):81-93.
PMID: 37952848
Commensal-specific clusters of differentiation (CD)4 T cells are expanded in patients with inflammatory bowel disease (IBD) compared to healthy individuals. How and where commensal-specific CD4 T cells get activated is...
6.
Hard J, Mold J, Eisfeldt J, Tellgren-Roth C, Haggqvist S, Bunikis I, et al.
Nat Commun
. 2023 Aug;
14(1):5164.
PMID: 37620373
Long-read sequencing has dramatically increased our understanding of human genome variation. Here, we demonstrate that long-read technology can give new insights into the genomic architecture of individual cells. Clonally expanded...
7.
Zimmer C, von Seth E, Buggert M, Strauss O, Hertwig L, Nguyen S, et al.
Sci Transl Med
. 2021 Jun;
13(599).
PMID: 34162753
The human biliary system, a mucosal barrier tissue connecting the liver and intestine, is an organ often affected by serious inflammatory and malignant diseases. Although these diseases are linked to...
8.
Mold J, Modolo L, Hard J, Zamboni M, Larsson A, Stenudd M, et al.
Cell Rep
. 2021 May;
35(8):109174.
PMID: 34038736
The CD8 T cell response to an antigen is composed of many T cell clones with unique T cell receptors, together forming a heterogeneous repertoire of effector and memory cells....
9.
Brownlie D, Scharenberg M, Mold J, Hard J, Kekalainen E, Buggert M, et al.
Proc Natl Acad Sci U S A
. 2021 Apr;
118(11).
PMID: 33836578
Human adaptive-like "memory" CD56CD16 natural killer (NK) cells in peripheral blood from cytomegalovirus-seropositive individuals have been extensively investigated in recent years and are currently explored as a treatment strategy for...
10.
Jiang X, Bergquist A, Loscher B, Venkatesh G, Mold J, Holm K, et al.
Sci Transl Med
. 2021 Feb;
13(582).
PMID: 33627483
Primary sclerosing cholangitis (PSC) is a chronic inflammatory liver disease without clear etiology or effective treatment. Genetic factors contribute to PSC pathogenesis, but so far, no causative mutation has been...