Jeannette N Stankowski
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Explore the profile of Jeannette N Stankowski including associated specialties, affiliations and a list of published articles.
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21
Citations
1346
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Recent Articles
1.
Chew J, Cook C, Gendron T, Jansen-West K, Del Rosso G, Daughrity L, et al.
Mol Neurodegener
. 2019 Feb;
14(1):9.
PMID: 30767771
Background: A GC hexanucleotide repeat expansion in the noncoding region of C9orf72 is the major genetic cause of frontotemporal dementia and amyotrophic lateral sclerosis (c9FTD/ALS). Putative disease mechanisms underlying c9FTD/ALS...
2.
Xiong Y, Neifert S, Karuppagounder S, Liu Q, Stankowski J, Lee B, et al.
Proc Natl Acad Sci U S A
. 2018 Feb;
115(7):1635-1640.
PMID: 29386392
Mutations in LRRK2 are known to be the most common genetic cause of sporadic and familial Parkinson's disease (PD). Multiple lines of LRRK2 transgenic or knockin mice have been developed,...
3.
Lee C, Stankowski J, Chew J, Cook C, Lam Y, Almeida S, et al.
Mol Neurodegener
. 2017 Jul;
12(1):55.
PMID: 28743268
Haploinsufficiency of GRN, the gene encoding progranulin (PGRN), causes frontotemporal lobar degeneration (FTLD), the second most common cause of early-onset dementia. Receptor-mediated lysosomal targeting has been shown to regulate brain...
4.
Gendron T, Chew J, Stankowski J, Hayes L, Zhang Y, Prudencio M, et al.
Sci Transl Med
. 2017 Mar;
9(383).
PMID: 28356511
There is no effective treatment for amyotrophic lateral sclerosis (ALS), a devastating motor neuron disease. However, discovery of a GC repeat expansion in the gene as the most common genetic...
5.
Xiong Y, Neifert S, Karuppagounder S, Stankowski J, Lee B, Grima J, et al.
eNeuro
. 2017 Mar;
4(2).
PMID: 28321439
Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene have been identified as an unambiguous cause of late-onset, autosomal-dominant familial Parkinson's disease (PD) and LRRK2 mutations are the strongest genetic...
6.
Zhang Y, Gendron T, Grima J, Sasaguri H, Jansen-West K, Xu Y, et al.
Nat Neurosci
. 2016 Mar;
19(5):668-677.
PMID: 26998601
Neuronal inclusions of poly(GA), a protein unconventionally translated from G4C2 repeat expansions in C9ORF72, are abundant in patients with frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) caused by this...
7.
Fiesel F, Ando M, Hudec R, Hill A, Castanedes-Casey M, Caulfield T, et al.
EMBO Rep
. 2015 Jul;
16(9):1114-30.
PMID: 26162776
Mutations in PINK1 and PARKIN cause recessive, early-onset Parkinson's disease (PD). Together, these two proteins orchestrate a protective mitophagic response that ensures the safe disposal of damaged mitochondria. The kinase...
8.
Chew J, Gendron T, Prudencio M, Sasaguri H, Zhang Y, Castanedes-Casey M, et al.
Science
. 2015 May;
348(6239):1151-4.
PMID: 25977373
The major genetic cause of frontotemporal dementia and amyotrophic lateral sclerosis is a G4C2 repeat expansion in C9ORF72. Efforts to combat neurodegeneration associated with "c9FTD/ALS" are hindered by a lack...
9.
Palubinsky A, Stankowski J, Kale A, Codreanu S, Singer R, Liebler D, et al.
Antioxid Redox Signal
. 2015 Jan;
23(6):535-49.
PMID: 25602369
Aims: Determine the mechanism by which C-terminus of HSC70-interacting protein (CHIP) induction alters neuronal survival under conditions of mitochondrial stress induced by oxygen glucose deprivation. Results: We report that animals...
10.
Zhang Y, Jansen-West K, Xu Y, Gendron T, Bieniek K, Lin W, et al.
Acta Neuropathol
. 2014 Sep;
128(4):505-24.
PMID: 25173361
The occurrence of repeat-associated non-ATG (RAN) translation, an atypical form of translation of expanded repeats that results in the synthesis of homopolymeric expansion proteins, is becoming more widely appreciated among...