Jean Davoust
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Explore the profile of Jean Davoust including associated specialties, affiliations and a list of published articles.
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28
Citations
1404
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Recent Articles
1.
Msallam R, Malissen B, Launay P, Blank U, Gautier G, Davoust J
Cells
. 2022 Oct;
11(19).
PMID: 36231017
Mast cells (MCs) are well-known for their role in IgE-mediated cutaneous anaphylactic responses, but their regulatory functions in the skin are still under intense scrutiny. Using a Red MC and...
2.
Rossignol J, Belaid Z, Fouquet G, Guillem F, Rignault R, Milpied P, et al.
iScience
. 2022 Jul;
25(6):104353.
PMID: 35874918
Targeting immune checkpoints, such as Programmed cell Death 1 (PD1), has improved survival in cancer patients by restoring antitumor immune responses. Most patients, however, relapse or are refractory to immune...
3.
Evnouchidou I, Chappert P, Benadda S, Zucchetti A, Weimershaus M, Bens M, et al.
Nat Commun
. 2020 Jun;
11(1):2779.
PMID: 32487999
T cell receptor (TCR) activation is modulated by mechanisms such as TCR endocytosis, which is thought to terminate TCR signalling. Here we show that, upon internalization, TCR continues to signal...
4.
Poupiot J, Costa Verdera H, Hardet R, Colella P, Collaud F, Bartolo L, et al.
Mol Ther Methods Clin Dev
. 2019 Oct;
15:83-100.
PMID: 31649958
The pro-tolerogenic environment of the liver makes this tissue an ideal target for gene replacement strategies. In other peripheral tissues such as the skeletal muscle, anti-transgene immune response can result...
5.
Bartolo L, Li Chung Tong S, Chappert P, Urbain D, Collaud F, Colella P, et al.
JCI Insight
. 2019 Jun;
4(11).
PMID: 31167976
Immune responses to therapeutic transgenes are a potential hurdle to treat monogenic muscle disorders. These responses result from the neutralizing activity of transgene-specific B cells and cytotoxic T cells recruited...
6.
Gross D, Ghenassia A, Bartolo L, Urbain D, Benkhelifa-Ziyyat S, Lorain S, et al.
J Virol
. 2018 Dec;
93(5).
PMID: 30541847
A key aspect to consider for vaccinal protection is the induction of a local line of defense consisting of nonrecirculating tissue-resident memory T cells (T), in parallel to the generation...
7.
Ngo Nyekel F, Pacreau E, Benadda S, Msallam R, Abrink M, Pejler G, et al.
Front Immunol
. 2018 Dec;
9:2690.
PMID: 30515167
Recent evidences indicate an important role of tissue inflammatory responses by innate immune cells in allograft acceptance and survival. Here we investigated the role of mast cells (MC) in an...
8.
Ghenassia A, Gross D, Lorain S, Tros F, Urbain D, Benkhelifa-Ziyyat S, et al.
Mol Ther
. 2017 Jul;
25(10):2309-2322.
PMID: 28720467
Recombinant adeno-associated viral (rAAV) vectors exhibit interesting properties as vaccine carriers for their ability to induce long-lasting antibody responses. However, rAAV-based vaccines have been suggested to trigger functionally impaired long-term...
9.
Carpentier M, Lorain S, Chappert P, Lalfer M, Hardet R, Urbain D, et al.
Mol Ther
. 2014 Dec;
23(4):697-706.
PMID: 25492560
Antitransgene CD8(+) T-cell responses are an important hurdle after recombinant adeno-associated virus (rAAV) vector-mediated gene transfer. Indeed, depending on the mutational genotype of the host, transgene amino-acid sequences of foreign...
10.
Dahdah A, Gautier G, Attout T, Fiore F, Lebourdais E, Msallam R, et al.
J Clin Invest
. 2014 Sep;
124(10):4577-89.
PMID: 25180604
Controlling the overwhelming inflammatory reaction associated with polymicrobial sepsis remains a prevalent clinical challenge with few treatment options. In septic peritonitis, blood neutrophils and monocytes are rapidly recruited into the...