Jayvardhan Pandit
Overview
Explore the profile of Jayvardhan Pandit including associated specialties, affiliations and a list of published articles.
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Articles
40
Citations
777
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Recent Articles
1.
Futatsugi K, Smith A, Tu M, Raymer B, Ahn K, Coffey S, et al.
J Med Chem
. 2020 Sep;
63(22):13546-13560.
PMID: 32910646
Increased fructose consumption and its subsequent metabolism have been implicated in metabolic disorders such as nonalcoholic fatty liver disease and steatohepatitis (NAFLD/NASH) and insulin resistance. Ketohexokinase (KHK) converts fructose to...
2.
Humphrey J, Movsesian M, Am Ende C, Becker S, Chappie T, Jenkinson S, et al.
J Med Chem
. 2018 May;
61(10):4635-4640.
PMID: 29718668
We disclose the discovery and X-ray cocrystal data of potent, selective quinazoline inhibitors of PDE1. Inhibitor ( S)-3 readily attains free plasma concentrations above PDE1 IC values and has restricted...
3.
Helal C, Arnold E, Boyden T, Chang C, Chappie T, Fennell K, et al.
J Med Chem
. 2018 Apr;
61(8):3753.
PMID: 29624389
No abstract available.
4.
McAllister L, Butler C, Mente S, ONeil S, Fonseca K, Piro J, et al.
J Med Chem
. 2018 Mar;
61(7):3008-3026.
PMID: 29498843
Monoacylglycerol lipase (MAGL) inhibition provides a potential treatment approach to neuroinflammation through modulation of both the endocannabinoid pathway and arachidonoyl signaling in the central nervous system (CNS). Herein we report...
5.
Helal C, Arnold E, Boyden T, Chang C, Chappie T, Fisher E, et al.
J Med Chem
. 2018 Jan;
61(3):1001-1018.
PMID: 29293004
Computational modeling was used to direct the synthesis of analogs of previously reported phosphodiesterase 2A (PDE2A) inhibitor 1 with an imidazotriazine core to yield compounds of significantly enhanced potency. The...
6.
Butler C, Beck E, Harris A, Huang Z, McAllister L, Am Ende C, et al.
J Med Chem
. 2017 Nov;
60(23):9860-9873.
PMID: 29148769
Monoacylglycerol lipase (MAGL) is the main enzyme responsible for degradation of the endocannabinoid 2-arachidonoylglycerol (2-AG) in the CNS. MAGL catalyzes the conversion of 2-AG to arachidonic acid (AA), a precursor...
7.
Huard K, Ahn K, Amor P, Beebe D, Borzilleri K, Chrunyk B, et al.
J Med Chem
. 2017 Aug;
60(18):7835-7849.
PMID: 28853885
Increased fructose consumption and its subsequent metabolism have been implicated in hepatic steatosis, dyslipidemia, obesity, and insulin resistance in humans. Since ketohexokinase (KHK) is the principal enzyme responsible for fructose...
8.
Helal C, Arnold E, Boyden T, Chang C, Chappie T, Fennell K, et al.
J Med Chem
. 2017 Jun;
60(13):5673-5698.
PMID: 28574706
Phosphodiesterase 2A (PDE2A) inhibitors have been reported to demonstrate in vivo activity in preclinical models of cognition. To more fully explore the biology of PDE2A inhibition, we sought to identify...
9.
Leverett C, Sukuru S, Vetelino B, Musto S, Parris K, Pandit J, et al.
ACS Med Chem Lett
. 2016 Nov;
7(11):999-1004.
PMID: 27882198
The tubulysin class of natural products has attracted much attention from the medicinal chemistry community due to its potent cytotoxicity against a wide range of human cancer cell lines, including...
10.
Ahn K, Boehm M, Brown M, Calloway J, Che Y, Chen J, et al.
ACS Chem Biol
. 2016 Jul;
11(9):2529-40.
PMID: 27391855
Lysophospholipase-like 1 (LYPLAL1) is an uncharacterized metabolic serine hydrolase. Human genome-wide association studies link variants of the gene encoding this enzyme to fat distribution, waist-to-hip ratio, and nonalcoholic fatty liver...