Christopher J ODonnell
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Explore the profile of Christopher J ODonnell including associated specialties, affiliations and a list of published articles.
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589
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Recent Articles
1.
Dimmeler S, Ferri L, Nioi P, ODonnell C, Damy T, Gomez-Outes A, et al.
Eur Heart J
. 2025 Feb;
PMID: 39969133
Cardiovascular diseases (CVD) remain the leading cause of death globally and there is an urgent need for innovative approaches to treatment. One emerging avenue is genetic therapies, which hold particular...
2.
Shen J, Valentim W, Friligkou E, Overstreet C, Choi K, Koller D, et al.
medRxiv
. 2024 Sep;
PMID: 39228734
Background: Patients with post-traumatic stress disorder (PTSD) experience higher risk of adverse cardiovascular (CV) outcomes. This study explores shared loci, and genes between PTSD and CV conditions from three major...
3.
Smith W, Nguyen D, Clough T, Schofield J, Kagan M, Kompa J, et al.
J Clin Endocrinol Metab
. 2024 Aug;
110(3):771-786.
PMID: 39148430
Background: Growth differentiation factor 15 (GDF15), a divergent member of the TGF-β superfamily, signals via the hindbrain glial-derived neurotrophic factor receptor alpha-like and rearranged during transfection receptor co-receptor (GFRAL-RET) complex....
4.
Verma A, Huffman J, Rodriguez A, Conery M, Liu M, Ho Y, et al.
Science
. 2024 Jul;
385(6706):eadj1182.
PMID: 39024449
One of the justifiable criticisms of human genetic studies is the underrepresentation of participants from diverse populations. Lack of inclusion must be addressed at-scale to identify causal disease factors and...
5.
Patel-Murray N, Zhang L, Claggett B, Xu D, Serrano-Fernandez P, Healey M, et al.
J Am Heart Assoc
. 2024 Jun;
13(13):e033544.
PMID: 38904251
Background: Prognostic markers and biological pathways linked to detrimental clinical outcomes in heart failure with preserved ejection fraction (HFpEF) remain incompletely defined. Methods And Results: We measured serum levels of...
6.
Pettersson M, Johnson D, Humphrey J, Am Ende C, Butler T, Dorff P, et al.
J Med Chem
. 2024 Jun;
67(12):10248-10262.
PMID: 38848667
Herein, we describe the design and synthesis of γ-secretase modulator (GSM) clinical candidate PF-06648671 () for the treatment of Alzheimer's disease. A key component of the design involved a 2,5--tetrahydrofuran...
7.
de Vries P, Conomos M, Singh K, Nicholson C, Jain D, Hasbani N, et al.
Nat Cardiovasc Res
. 2024 May;
2(12):1159-1172.
PMID: 38817323
Coronary artery calcification (CAC) is a measure of atherosclerosis and a well-established predictor of coronary artery disease (CAD) events. Here we describe a genome-wide association study (GWAS) of CAC in...
8.
Keaton J, Kamali Z, Xie T, Vaez A, Williams A, Goleva S, et al.
Nat Genet
. 2024 Apr;
56(5):778-791.
PMID: 38689001
Hypertension affects more than one billion people worldwide. Here we identify 113 novel loci, reporting a total of 2,103 independent genetic signals (P < 5 × 10) from the largest...
9.
Small A, Melloni G, Kamanu F, Bergmark B, Bonaca M, ODonoghue M, et al.
JAMA Cardiol
. 2024 Feb;
9(4):357-366.
PMID: 38416462
Importance: Polygenic risk scores (PRSs) have proven to be as strong as or stronger than established clinical risk factors for many cardiovascular phenotypes. Whether this is true for aortic stenosis...
10.
Rogers M, Bartoli-Leonard F, Zheng K, Small A, Chen H, Clift C, et al.
Circulation
. 2023 Nov;
149(5):391-401.
PMID: 37937463
Background: High circulating levels of Lp(a) (lipoprotein[a]) increase the risk of atherosclerosis and calcific aortic valve disease, affecting millions of patients worldwide. Although atherosclerosis is commonly treated with low-density lipoprotein-targeting...