Javier Varona Santos
Overview
Explore the profile of Javier Varona Santos including associated specialties, affiliations and a list of published articles.
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Articles
11
Citations
266
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0
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Recent Articles
1.
Rojas M, Pereira-Simon S, Zigmond Z, Varona Santos J, Perla M, Santos Falcon N, et al.
Cells
. 2024 May;
13(10).
PMID: 38786017
Arteries and veins develop different types of occlusive diseases and respond differently to injury. The biological reasons for this discrepancy are not well understood, which is a limiting factor for...
2.
Ito M, Ducasa G, Molina J, Varona Santos J, Mallela S, Kim J, et al.
Sci Rep
. 2023 Jun;
13(1):9616.
PMID: 37316538
Decreased ATP Binding Cassette Transporter A1 (ABCA1) expression and caspase-4-mediated noncanonical inflammasome contribution have been described in podocytes in diabetic kidney disease (DKD). To investigate a link between these pathways,...
3.
Ge M, Molina J, Kim J, Mallela S, Ahmad A, Varona Santos J, et al.
Elife
. 2023 May;
12.
PMID: 37129368
Sodium-glucose cotransporter-2 inhibitors (SGLT2i) are anti-hyperglycemic agents that prevent glucose reabsorption in proximal tubular cells. SGLT2i improves renal outcomes in both diabetic and non-diabetic patients, indicating it may have beneficial...
4.
Mallela S, Ge M, Molina J, Varona Santos J, Kim J, Mitrofanova A, et al.
Genes Dis
. 2022 Feb;
9(6):1397-1400.
PMID: 35224168
No abstract available.
5.
Wright M, Varona Santos J, Kemmer C, Maugeais C, Carralot J, Roever S, et al.
Nat Commun
. 2021 Aug;
12(1):4662.
PMID: 34341345
Impaired cellular cholesterol efflux is a key factor in the progression of renal, cardiovascular, and autoimmune diseases. Here we describe a class of 5-arylnicotinamide compounds, identified through phenotypic drug discovery,...
6.
Ge M, Molina J, Ducasa G, Mallela S, Varona Santos J, Mitrofanova A, et al.
Hum Mol Genet
. 2021 Jan;
30(3-4):182-197.
PMID: 33517446
Lipotoxicity was recently reported in several forms of kidney disease, including focal segmental glomerulosclerosis (FSGS). Susceptibility to FSGS in African Americans is associated with the presence of genetic variants of...
7.
Sterol-O-acyltransferase-1 has a role in kidney disease associated with diabetes and Alport syndrome
Liu X, Ducasa G, Mallela S, Kim J, Molina J, Mitrofanova A, et al.
Kidney Int
. 2020 Aug;
98(5):1275-1285.
PMID: 32739420
Defective cholesterol metabolism primarily linked to reduced ATP-binding cassette transporter A1 (ABCA1) expression is closely associated with the pathogenesis and progression of kidney diseases, including diabetic kidney disease and Alport...
8.
Ducasa G, Mitrofanova A, Mallela S, Liu X, Molina J, Sloan A, et al.
J Clin Invest
. 2019 Jul;
129(8):3387-3400.
PMID: 31329164
Fibroblasts from patients with Tangier disease carrying ATP-binding cassette A1 (ABCA1) loss-of-function mutations are characterized by cardiolipin accumulation, a mitochondrial-specific phospholipid. Suppression of ABCA1 expression occurs in glomeruli from patients...
9.
Richter H, Satz A, Bedoucha M, Buettelmann B, Petersen A, Harmeier A, et al.
ACS Chem Biol
. 2018 Nov;
14(1):37-49.
PMID: 30452219
The importance of Discoidin Domain Receptor 1 (DDR1) in renal fibrosis has been shown via gene knockout and use of antisense oligonucleotides; however, these techniques act via a reduction of...
10.
Mitrofanova A, Molina J, Varona Santos J, Guzman J, Morales X, Ducasa G, et al.
Kidney Int
. 2018 Oct;
94(6):1151-1159.
PMID: 30301568
Studies suggest that altered renal lipid metabolism plays a role in the pathogenesis of diabetic kidney disease and that genetic or pharmacological induction of cholesterol efflux protects from the development...