Jason J Serpa
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Explore the profile of Jason J Serpa including associated specialties, affiliations and a list of published articles.
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Articles
17
Citations
259
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Recent Articles
1.
Serpa J, Popov K, Petrotchenko E, Dokholyan N, Borchers C
Proteomics
. 2021 Sep;
21(21-22):e2000298.
PMID: 34482645
The conversion of the native monomeric cellular prion protein (PrP ) into an aggregated pathological β-oligomeric form (PrP ) and an infectious form (PrP ) is the central element in...
2.
Dilworth D, Gudavicius G, Xu X, Boyce A, OSullivan C, Serpa J, et al.
Nucleic Acids Res
. 2018 Jan;
46(5):2459-2478.
PMID: 29361176
FK506 binding proteins (FKBPs) catalyze the interconversion of cis-trans proline conformers in proteins. Importantly, FK506 drugs have anti-cancer and neuroprotective properties, but the effectors and mechanisms underpinning these properties are...
3.
Dilworth D, Upadhyay S, Bonnafous P, Edoo A, Bourbigot S, Pesek-Jardim F, et al.
Nucleic Acids Res
. 2017 Oct;
45(20):11989-12004.
PMID: 29036638
Prolyl isomerases are defined by a catalytic domain that facilitates the cis-trans interconversion of proline residues. In most cases, additional domains in these enzymes add important biological function, including recruitment...
4.
Ellard K, Serpa J, Petrotchenko E, Borchers C, Ausio J
Biochem Biophys Rep
. 2017 Sep;
6:165-171.
PMID: 28955874
Mouse nucleoplasmin M.NPM2 was recombinantly expressed and the protein consisting of the complete sequence was purified and characterized. Similar to its X.NPM2 counterpart, the protein forms stable pentameric complexes and...
5.
Makepeace K, Serpa J, Petrotchenko E, Borchers C
Methods
. 2015 Mar;
89:74-8.
PMID: 25752848
Disulfide bonds are valuable constraints in protein structure modeling. The Cys-Cys disulfide bond undergoes specific fragmentation under CID and, therefore, can be considered as a CID-cleavable crosslink. We have recently...
6.
Petrotchenko E, Serpa J, Makepeace K, Brodie N, Borchers C
J Proteomics
. 2014 Jun;
109:104-10.
PMID: 24972318
Biological Significance: The new (14)N(15)N DXMSMS Match software program is a practical tool for the efficient assignment of crosslinks from LC-MS/MS experiments using an equimolar mixture of non-labeled and (15)N...
7.
The prolyl isomerase, FKBP25, interacts with RNA-engaged nucleolin and the pre-60S ribosomal subunit
Gudavicius G, Dilworth D, Serpa J, Sessler N, Petrotchenko E, Borchers C, et al.
RNA
. 2014 May;
20(7):1014-22.
PMID: 24840943
Peptidyl-proline isomerases of the FK506-binding protein (FKBP) family belong to a class of enzymes that catalyze the cis-trans isomerization of prolyl-peptide bonds in proteins. A handful of FKBPs are found...
8.
Petrotchenko E, Makepeace K, Serpa J, Borchers C
Methods Mol Biol
. 2014 May;
1156:447-63.
PMID: 24792007
Cross-linking combined with mass spectrometry is a powerful technique to study protein structure. Here, we present an optimized protocol for the preparation, processing, and analysis of a protein sample cross-linked...
9.
Petrotchenko E, Serpa J, Cabecinha A, Lesperance M, Borchers C
J Proteome Res
. 2013 Dec;
13(2):527-35.
PMID: 24354799
SDS-PAGE is one of the most powerful protein separation techniques, and in-gel digestion is the leading method for converting proteins separated by SDS-PAGE into peptides suitable for mass spectrometry-based proteomic...
10.
Serpa J, Makepeace K, Borchers T, Wishart D, Petrotchenko E, Borchers C
J Proteomics
. 2013 Dec;
100:160-6.
PMID: 24316355
Biological Significance: Surface modification using isotopically-coded hydrogen peroxide has allowed quantitative comparison of the exposure of methionine and tryptophan residues in PrP(C) and PrP(ß) forms of prion protein. Detected changes...