David Dilworth
Overview
Explore the profile of David Dilworth including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
28
Citations
364
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Douvaras P, Buenaventura D, Sun B, Lepack A, Baker E, Simpson E, et al.
Nat Commun
. 2024 Sep;
15(1):8132.
PMID: 39284802
Mucopolysaccharidoses are inherited metabolic disorders caused by the deficiency in lysosomal enzymes required to break down glycosaminoglycans. Accumulation of glycosaminoglycans leads to progressive, systemic degenerative disease. The central nervous system...
2.
Hanley R, Nie D, Tabor J, Li F, Sobh A, Xu C, et al.
J Am Chem Soc
. 2023 Mar;
145(14):8176-8188.
PMID: 36976643
Nuclear receptor-binding SET domain-containing 2 (NSD2) plays important roles in gene regulation, largely through its ability to dimethylate lysine 36 of histone 3 (H3K36me2). Despite aberrant activity of NSD2 reported...
3.
Szewczyk M, Luciani G, Vu V, Murison A, Dilworth D, Barghout S, et al.
Redox Biol
. 2022 Mar;
51:102282.
PMID: 35305370
Protein methyltransferase 5 (PRMT5) symmetrically dimethylates arginine residues leading to regulation of transcription and splicing programs. Although PRMT5 has emerged as an attractive oncology target, the molecular determinants of PRMT5...
4.
Dilworth D, Hanley R, Ferreira de Freitas R, Allali-Hassani A, Zhou M, Mehta N, et al.
Nat Chem Biol
. 2021 Nov;
18(1):56-63.
PMID: 34782742
Nuclear receptor-binding SET domain-containing 2 (NSD2) is the primary enzyme responsible for the dimethylation of lysine 36 of histone 3 (H3K36), a mark associated with active gene transcription and intergenic...
5.
Zhou M, Abdali S, Dilworth D, Liu L, Cole B, Malhan N, et al.
J Vis Exp
. 2021 Mar;
(169).
PMID: 33749685
Histones belong to a family of highly conserved proteins in eukaryotes. They pack DNA into nucleosomes as functional units of chromatin. Post-translational modifications (PTMs) of histones, which are highly dynamic...
6.
Calhoun S, Bell T, Dahlin L, Kunde Y, Labutti K, Louie K, et al.
Commun Biol
. 2021 Mar;
4(1):333.
PMID: 33712730
Microalgae efficiently convert sunlight into lipids and carbohydrates, offering bio-based alternatives for energy and chemical production. Improving algal productivity and robustness against abiotic stress requires a systems level characterization enabled...
7.
Ferreira de Freitas R, Liu Y, Szewczyk M, Mehta N, Li F, McLeod D, et al.
J Med Chem
. 2021 Feb;
64(3):1584-1592.
PMID: 33522809
Increased activity of the lysine methyltransferase NSD2 driven by translocation and activating mutations is associated with multiple myeloma and acute lymphoblastic leukemia, but no NSD2-targeting chemical probe has been reported...
8.
Szewczyk M, Ishikawa Y, Organ S, Sakai N, Li F, Halabelian L, et al.
Nat Commun
. 2020 May;
11(1):2683.
PMID: 32457299
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
9.
Szewczyk M, Ishikawa Y, Organ S, Sakai N, Li F, Halabelian L, et al.
Nat Commun
. 2020 May;
11(1):2396.
PMID: 32409666
Protein arginine methyltransferases (PRMTs) regulate diverse biological processes and are increasingly being recognized for their potential as drug targets. Here we report the discovery of a potent, selective, and cell-active...
10.
Allali-Hassani A, Szewczyk M, Ivanochko D, Organ S, Bok J, Ho J, et al.
Nat Commun
. 2019 Dec;
10(1):5759.
PMID: 31848333
PRDM9 is a PR domain containing protein which trimethylates histone 3 on lysine 4 and 36. Its normal expression is restricted to germ cells and attenuation of its activity results...