(14)N(15)N DXMSMS Match Program for the Automated Analysis of LC/ESI-MS/MS Crosslinking Data from Experiments Using (15)N Metabolically Labeled Proteins

Biological Significance: The new (14)N(15)N DXMSMS Match software program is a practical tool for the efficient assignment of crosslinks from LC-MS/MS experiments using an equimolar mixture of non-labeled and (15)N metabolically labeled proteins. It greatly facilitates automated data analysis from complicated crosslinking experiments, such as those using zero-length crosslinkers and those involving only a few crosslinking and digestion site restrictions.