Jason D Berndt
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Explore the profile of Jason D Berndt including associated specialties, affiliations and a list of published articles.
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23
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1112
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Recent Articles
11.
James R, Bosch K, Kulikauskas R, Yang P, Robin N, Toroni R, et al.
J Biol Chem
. 2013 Oct;
288(48):34658-70.
PMID: 24114839
Advances in phosphoproteomics have made it possible to monitor changes in protein phosphorylation that occur at different steps in signal transduction and have aided the identification of new pathway components....
12.
Korvatska O, Strand N, Berndt J, Strovas T, Chen D, Leverenz J, et al.
Hum Mol Genet
. 2013 Apr;
22(16):3259-68.
PMID: 23595882
We report a novel gene for a parkinsonian disorder. X-linked parkinsonism with spasticity (XPDS) presents either as typical adult onset Parkinson's disease or earlier onset spasticity followed by parkinsonism. We...
13.
Davidson K, Adams A, Goodson J, McDonald C, Potter J, Berndt J, et al.
Proc Natl Acad Sci U S A
. 2012 Mar;
109(12):4485-90.
PMID: 22392999
Signal transduction pathways play diverse, context-dependent roles in vertebrate development. In studies of human embryonic stem cells (hESCs), conflicting reports claim Wnt/β-catenin signaling promotes either self-renewal or differentiation. We use...
14.
Berndt J, Aoyagi A, Yang P, Anastas J, Tang L, Moon R
J Cell Biol
. 2011 Aug;
194(5):737-50.
PMID: 21875946
Receptor-like tyrosine kinase (RYK) functions as a transmembrane receptor for the Wnt family of secreted protein ligands. Although RYK undergoes endocytosis in response to Wnt, the mechanisms that regulate its...
15.
Klinghoffer R, Frazier J, Annis J, Berndt J, Roberts B, Arthur W, et al.
PLoS One
. 2009 Sep;
4(9):e6892.
PMID: 19727391
The multi-protein beta-catenin destruction complex tightly regulates beta-catenin protein levels by shuttling beta-catenin to the proteasome. Glycogen synthase kinase 3beta (GSK3beta), a key serine/threonine kinase in the destruction complex, is...
16.
Berndt J, Biechele T, Moon R, Major M
Sci Signal
. 2009 May;
2(70):pt4.
PMID: 19436058
High-throughput genetic screens have exponentially increased the functional annotation of the genome over the past 10 years. Likewise, genome-scale efforts to map DNA methylation, chromatin state and occupancy, messenger RNA...
17.
Berndt J, Moon R, Major M
Trends Biochem Sci
. 2009 Feb;
34(3):101-4.
PMID: 19217300
Numerous studies have pointed to interactions between the tumor suppressor von Hippel-Lindau (VHL) and the oncogenic Wnt-beta-catenin signaling cascade; however, the mechanism of this crosstalk has remained elusive. Among other...
18.
Major M, Roberts B, Berndt J, Marine S, Anastas J, Chung N, et al.
Sci Signal
. 2008 Nov;
1(45):ra12.
PMID: 19001663
The identification and characterization of previously unidentified signal transduction molecules has expanded our understanding of biological systems and facilitated the development of mechanism-based therapeutics. We present a highly validated small...
19.
Berndt J, Clay M, Langenberg T, Halloran M
Dev Biol
. 2008 Oct;
324(2):236-44.
PMID: 18926812
The induction and migration of neural crest cells (NCCs) are essential to the development of craniofacial structures and the peripheral nervous system. A critical step in the development of NCCs...
20.
Xing Y, Takemaru K, Liu J, Berndt J, Zheng J, Moon R, et al.
Structure
. 2008 Mar;
16(3):478-87.
PMID: 18334222
beta-catenin plays essential roles in cell adhesion and Wnt signaling, while deregulation of beta-catenin is associated with multiple diseases including cancers. Here, we report the crystal structures of full-length zebrafish...