Jared J Gartner
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Explore the profile of Jared J Gartner including associated specialties, affiliations and a list of published articles.
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53
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5032
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Recent Articles
31.
Deniger D, Pasetto A, Robbins P, Gartner J, Prickett T, Paria B, et al.
Clin Cancer Res
. 2018 Jun;
24(22):5562-5573.
PMID: 29853601
This was a study prospectively evaluating intratumoral T-cell responses to autologous somatic mutated neoepitopes expressed by human metastatic ovarian cancers. Tumor-infiltrating lymphocytes (TIL) were expanded from resected ovarian cancer metastases,...
32.
Qutob N, Masuho I, Alon M, Emmanuel R, Cohen I, Di Pizio A, et al.
Sci Rep
. 2018 Jan;
8(1):653.
PMID: 29330521
Analysis of 501 melanoma exomes revealed RGS7, which encodes a GTPase-accelerating protein (GAP), to be a tumor-suppressor gene. RGS7 was mutated in 11% of melanomas and was found to harbor...
33.
Lu Y, Zheng Z, Robbins P, Tran E, Prickett T, Gartner J, et al.
Mol Ther
. 2017 Nov;
26(2):379-389.
PMID: 29174843
The adoptive transfer of neoantigen-reactive tumor-infiltrating lymphocytes (TILs) can result in tumor regression in patients with metastatic cancer. To improve the efficacy of adoptive T cell therapy targeting these tumor-specific...
34.
Prickett T, Gartner J, Samuels Y
Methods Mol Biol
. 2017 Oct;
1677:93-116.
PMID: 28986867
Ionotropic glutamate receptors (iGluRs) are large integral membrane multi-protein complexes that create ion channels in plasma membranes. Upon binding of receptor specific ligands (e.g., glutamate), increased efflux or influx of...
35.
Patel S, Sanjana N, Kishton R, Eidizadeh A, Vodnala S, Cam M, et al.
Nature
. 2017 Aug;
548(7669):537-542.
PMID: 28783722
Somatic gene mutations can alter the vulnerability of cancer cells to T-cell-based immunotherapies. Here we perturbed genes in human melanoma cells to mimic loss-of-function mutations involved in resistance to these...
36.
Stevanovic S, Pasetto A, Helman S, Gartner J, Prickett T, Howie B, et al.
Science
. 2017 Apr;
356(6334):200-205.
PMID: 28408606
Immunotherapy has clinical activity in certain virally associated cancers. However, the tumor antigens targeted in successful treatments remain poorly defined. We used a personalized immunogenomic approach to elucidate the global...
37.
Assadipour Y, Zacharakis N, Crystal J, Prickett T, Gartner J, Somerville R, et al.
Clin Cancer Res
. 2017 Apr;
23(15):4347-4353.
PMID: 28377481
The administration of autologous tumor-infiltrating lymphocytes (TILs) can mediate durable tumor regressions in patients with melanoma likely based on the recognition of immunogenic somatic mutations expressed by the cancer. There...
38.
Tran E, Robbins P, Lu Y, Prickett T, Gartner J, Jia L, et al.
N Engl J Med
. 2016 Dec;
375(23):2255-2262.
PMID: 27959684
We identified a polyclonal CD8+ T-cell response against mutant KRAS G12D in tumor-infiltrating lymphocytes obtained from a patient with metastatic colorectal cancer. We observed objective regression of all seven lung...
39.
Prickett T, Crystal J, Cohen C, Pasetto A, Parkhurst M, Gartner J, et al.
Cancer Immunol Res
. 2016 Jun;
4(8):669-78.
PMID: 27312342
Immunotherapy treatment of patients with metastatic cancer has assumed a prominent role in the clinic. Durable complete response rates of 20% to 25% are achieved in patients with metastatic melanoma...
40.
Gros A, Parkhurst M, Tran E, Pasetto A, Robbins P, Ilyas S, et al.
Nat Med
. 2016 Feb;
22(4):433-8.
PMID: 26901407
Detection of lymphocytes that target tumor-specific mutant neoantigens--derived from products encoded by mutated genes in the tumor--is mostly limited to tumor-resident lymphocytes, but whether these lymphocytes often occur in the...