Janni Petersen
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Explore the profile of Janni Petersen including associated specialties, affiliations and a list of published articles.
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Articles
36
Citations
817
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Recent Articles
1.
Smiles W, Ovens A, Yu D, Ling N, Poblete Goycoolea A, Morrison K, et al.
NPJ Metab Health Dis
. 2025 Mar;
3(1):8.
PMID: 40052110
The nutrient-sensitive protein kinases AMPK and mTORC1 form a fundamental negative feedback loop that governs cell growth and proliferation. mTORC1 phosphorylates α2-S345 in the AMPK αβγ heterotrimer to suppress its...
2.
Gillespie A, Mehdorn A, Lim T, Wang T, Mooney B, Ovens A, et al.
NPJ Metab Health Dis
. 2025 Feb;
3(1):5.
PMID: 39991135
Metformin is a well-tolerated drug frequently prescribed for managing type 2 diabetes. Extended metformin use has been linked to a significant decrease in cancer incidence across both diabetic and non-diabetic...
3.
Smiles W, Ovens A, Kemp B, Galic S, Petersen J, Oakhill J
Essays Biochem
. 2024 Jul;
68(3):321-336.
PMID: 38994736
Metabolic homeostasis and the ability to link energy supply to demand are essential requirements for all living cells to grow and proliferate. Key to metabolic homeostasis in all eukaryotes are...
4.
Orang A, Marri S, McKinnon R, Petersen J, Michael M
Cancers (Basel)
. 2024 Jun;
16(11).
PMID: 38893174
Background: Metformin is a first-line therapy for type 2 diabetes as it disrupts cellular metabolism. Despite the association between metformin and lower cancer incidence, the anti-tumour activity of the drug...
5.
Morrison K, Wang T, Chan K, Trotter E, Gillespie A, Michael M, et al.
Open Biol
. 2023 Apr;
13(4):230021.
PMID: 37042113
Expression and activity of the AMP-activated protein kinase (AMPK) 1 catalytic subunit of the heterotrimeric kinase significantly correlates with poor outcome for colorectal cancer patients. Hence there is considerable interest...
6.
Smith N, Spencer-Merris P, Fox A, Petersen J, Michael M
Cancers (Basel)
. 2022 Sep;
14(18).
PMID: 36139550
The long noncoding RNA is known to be heavily dysregulated in many cancers. A single exon gene produces two isoforms, and through alternative 3'-end processing. As the longer isoform, is...
7.
Orang A, Ali S, Petersen J, McKinnon R, Aloia A, Michael M
Sci Rep
. 2022 Feb;
12(1):2889.
PMID: 35190587
Metformin inhibits oxidative phosphorylation and can be used to dissect metabolic pathways in colorectal cancer (CRC) cells. CRC cell proliferation is inhibited by metformin in a dose dependent manner. MicroRNAs...
8.
Morrison K, Smiles W, Ling N, Hoque A, Shea G, Ngoei K, et al.
Cell Rep
. 2022 Feb;
38(7):110365.
PMID: 35172150
AMP-activated protein kinase (AMPK) and mechanistic target of rapamycin complex 1 (mTORC1) are metabolic kinases that co-ordinate nutrient supply with cell growth. AMPK negatively regulates mTORC1, and mTORC1 reciprocally phosphorylates...
9.
Wang T, Woodman P, Humphrey S, Petersen J
Life Sci Alliance
. 2022 Feb;
5(5).
PMID: 35121625
Cells respond to changing nutrient environments by adjusting the abundance of surface nutrient transporters and receptors. This can be achieved by modulating ubiquitin-dependent endocytosis, which in part is regulated by...
10.
Needham E, Hingst J, Parker B, Morrison K, Yang G, Onslev J, et al.
Nat Biotechnol
. 2021 Dec;
40(4):576-584.
PMID: 34857927
Protein phosphorylation dynamically integrates environmental and cellular information to control biological processes. Identifying functional phosphorylation amongst the thousands of phosphosites regulated by a perturbation at a global scale is a...