Iain M Hagan
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Explore the profile of Iain M Hagan including associated specialties, affiliations and a list of published articles.
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1045
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Recent Articles
1.
Morrison K, Wang T, Chan K, Trotter E, Gillespie A, Michael M, et al.
Open Biol
. 2023 Apr;
13(4):230021.
PMID: 37042113
Expression and activity of the AMP-activated protein kinase (AMPK) 1 catalytic subunit of the heterotrimeric kinase significantly correlates with poor outcome for colorectal cancer patients. Hence there is considerable interest...
2.
Halova L, Cobley D, Franz-Wachtel M, Wang T, Morrison K, Krug K, et al.
Open Biol
. 2021 Apr;
11(4):200405.
PMID: 33823663
Fluctuations in TOR, AMPK and MAP-kinase signalling maintain cellular homeostasis and coordinate growth and division with environmental context. We have applied quantitative, SILAC mass spectrometry to map TOR and nutrient-controlled...
3.
Forte G, Davie E, Lie S, Franz-Wachtel M, Ovens A, Wang T, et al.
J Cell Sci
. 2019 Mar;
132(7).
PMID: 30814334
AMP-activated kinase (AMPK) and target of rapamycin (TOR) signalling coordinate cell growth, proliferation, metabolism and cell survival with the nutrient environment of cells. The poor vasculature and nutritional stress experienced...
4.
Chan K, Alonso-Nunez M, Grallert A, Tanaka K, Connolly Y, Smith D, et al.
J Cell Biol
. 2017 Aug;
216(9):2795-2812.
PMID: 28774892
The fission yeast scaffold molecule Sid4 anchors the septum initiation network to the spindle pole body (SPB, centrosome equivalent) to control mitotic exit events. A second SPB-associated scaffold, Cut12, promotes...
5.
Grallert A, Hagan I
Cold Spring Harb Protoc
. 2017 Mar;
2017(3).
PMID: 28250233
Biochemical monitoring and interrogation of protein function is a critical component of most fission yeast studies. In particular, its small proteome size, high conservation of core molecular cell biology, and...
6.
Grallert A, Hagan I
Cold Spring Harb Protoc
. 2017 Feb;
2017(2).
PMID: 28148853
We outline immunoprecipitation (IP) procedures to isolate the large quantities of a molecule of interest that are required to identify posttranslational modifications (PTMs) in subsequent targeted mass spectrometry analysis. In...
7.
Grallert A, Hagan I
Cold Spring Harb Protoc
. 2017 Feb;
2017(2).
PMID: 28148852
We describe procedures for the immunoprecipitation (IP) of a molecule of interest from cell extracts under native or denaturing conditions. The methods are equally effective with antibodies that directly recognize...
8.
Grallert A, Hagan I
Cold Spring Harb Protoc
. 2017 Feb;
2017(2).
PMID: 28148851
Schizosaccharomyces pombe is an attractive model organism with which to study core principles of conserved molecular cell biology processes. The ability to monitor protein behavior following separation by sodium dodecyl...
9.
Hagan I, Grallert A, Simanis V
Cold Spring Harb Protoc
. 2016 Sep;
2016(9).
PMID: 27587785
Schizosaccharomyces pombe cells are rod shaped, and they grow by tip elongation. Growth ceases during mitosis and cell division; therefore, the length of a septated cell is a direct measure...
10.
Hagan I, Grallert A, Simanis V
Cold Spring Harb Protoc
. 2016 Aug;
2016(8).
PMID: 27480720
Transient inactivation of the cdc25(+) gene product by manipulation of the culture temperature for cdc25-22 cells is the most commonly exploited approach to mitotic synchronization in fission yeast. Because Cdc25...