Janna Armstrong
Overview
Explore the profile of Janna Armstrong including associated specialties, affiliations and a list of published articles.
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Articles
4
Citations
31
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Recent Articles
1.
Goswami D, Arredondo S, Betz W, Armstrong J, Kumar S, Zanghi G, et al.
Commun Biol
. 2024 Oct;
7(1):1387.
PMID: 39455824
Malaria, caused by Plasmodium parasites, imposes a significant health burden and live-attenuated parasites are being pursued as vaccines. Here, we report on the creation of a genetically attenuated parasite by...
2.
Goswami D, Patel H, Betz W, Armstrong J, Camargo N, Patil A, et al.
EMBO Mol Med
. 2024 Mar;
16(4):723-754.
PMID: 38514791
Vaccination with infectious Plasmodium falciparum (Pf) sporozoites (SPZ) administered with antimalarial drugs (PfSPZ-CVac), confers superior sterilizing protection against infection when compared to vaccination with replication-deficient, radiation-attenuated PfSPZ. However, the requirement...
3.
Patel H, Minkah N, Kumar S, Zanghi G, Schepis A, Goswami D, et al.
Nat Commun
. 2024 Mar;
15(1):2104.
PMID: 38453916
Malaria-causing Plasmodium parasites first replicate as liver stages (LS), which then seed symptomatic blood stage (BS) infection. Emerging evidence suggests that these stages impact each other via perturbation of host...
4.
Murphy S, Vaughan A, Kublin J, Fishbauger M, Seilie A, Cruz K, et al.
Sci Transl Med
. 2022 Aug;
14(659):eabn9709.
PMID: 36001680
Genetically engineered live sporozoites constitute a potential platform for creating consistently attenuated, genetically defined, whole-parasite vaccines against malaria through targeted gene deletions. Such genetically attenuated parasites (GAPs) do not require...