Stefan H I Kappe
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Explore the profile of Stefan H I Kappe including associated specialties, affiliations and a list of published articles.
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180
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6979
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Recent Articles
1.
Zanghi G, Patel H, Smith J, Camargo N, Bae Y, Hesping E, et al.
Nat Microbiol
. 2025 Jan;
10(2):569-584.
PMID: 39891010
Gene expression of Plasmodium falciparum (Pf) liver-stage (LS) parasites has remained poorly characterized, although they are major vaccine and drug targets. Using a human liver-chimaeric mouse model and a fluorescent...
2.
3.
Goswami D, Arredondo S, Betz W, Armstrong J, Kumar S, Zanghi G, et al.
Commun Biol
. 2024 Oct;
7(1):1387.
PMID: 39455824
Malaria, caused by Plasmodium parasites, imposes a significant health burden and live-attenuated parasites are being pursued as vaccines. Here, we report on the creation of a genetically attenuated parasite by...
4.
Kane J, Li X, Kumar S, Button-Simons K, Vendrely Brenneman K, Dahlhoff H, et al.
mBio
. 2024 Jun;
15(7):e0080524.
PMID: 38912775
Piperaquine (PPQ) is widely used in combination with dihydroartemisinin as a first-line treatment against malaria. Multiple genetic drivers of PPQ resistance have been reported, including mutations in the () and...
5.
Patel H, Minkah N, Kumar S, Zanghi G, Schepis A, Goswami D, et al.
Nat Commun
. 2024 Mar;
15(1):2104.
PMID: 38453916
Malaria-causing Plasmodium parasites first replicate as liver stages (LS), which then seed symptomatic blood stage (BS) infection. Emerging evidence suggests that these stages impact each other via perturbation of host...
6.
Kane J, Li X, Kumar S, Button-Simons K, Vendrely Brenneman K, Dahlhoff H, et al.
bioRxiv
. 2023 Sep;
PMID: 37745488
Piperaquine (PPQ) is widely used in combination with dihydroartemisinin (DHA) as a first-line treatment against malaria parasites. Multiple genetic drivers of PPQ resistance have been reported, including mutations in the...
7.
Richie T, Church L, Murshedkar T, Billingsley P, James E, Chen M, et al.
Expert Rev Vaccines
. 2023 Aug;
22(1):964-1007.
PMID: 37571809
Introduction: Malaria, a devastating febrile illness caused by protozoan parasites, sickened 247,000,000 people in 2021 and killed 619,000, mostly children and pregnant women in sub-Saharan Africa. A highly effective vaccine...
8.
Mauer S, Camargo N, Abatiyow B, Gargaro O, Kappe S, Kumar S
mBio
. 2023 Aug;
14(4):e0082223.
PMID: 37535401
Sexual reproduction of the malaria parasites is critical for their transmission to a mosquito vector. Several signaling molecules, such as kinases and phosphatases, are known to regulate this process. We...
9.
Jennison C, Armstrong J, Dankwa D, Hertoghs N, Kumar S, Abatiyow B, et al.
Mol Microbiol
. 2023 Jun;
121(3):394-412.
PMID: 37314965
Plasmodium parasites, the eukaryotic pathogens that cause malaria, feature three distinct invasive forms tailored to the host environment they must navigate and invade for life cycle progression. One conserved feature...
10.
Chavtur C, Staubus W, Ho M, Hergott D, Seilie A, Healy S, et al.
Open Forum Infect Dis
. 2023 Jun;
10(5):ofad202.
PMID: 37265668
Background: Sensitive molecular assays, such as quantitative reverse-transcription polymerase chain reaction (qRT-PCR) of 18S ribosomal RNA (rRNA), are increasingly the primary method of detecting infections in controlled human malaria infection...