William Betz
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Explore the profile of William Betz including associated specialties, affiliations and a list of published articles.
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8
Citations
83
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Recent Articles
1.
Zanghi G, Patel H, Smith J, Camargo N, Bae Y, Hesping E, et al.
Nat Microbiol
. 2025 Jan;
10(2):569-584.
PMID: 39891010
Gene expression of Plasmodium falciparum (Pf) liver-stage (LS) parasites has remained poorly characterized, although they are major vaccine and drug targets. Using a human liver-chimaeric mouse model and a fluorescent...
2.
Goswami D, Arredondo S, Betz W, Armstrong J, Kumar S, Zanghi G, et al.
Commun Biol
. 2024 Oct;
7(1):1387.
PMID: 39455824
Malaria, caused by Plasmodium parasites, imposes a significant health burden and live-attenuated parasites are being pursued as vaccines. Here, we report on the creation of a genetically attenuated parasite by...
3.
Goswami D, Patel H, Betz W, Armstrong J, Camargo N, Patil A, et al.
EMBO Mol Med
. 2024 Mar;
16(4):723-754.
PMID: 38514791
Vaccination with infectious Plasmodium falciparum (Pf) sporozoites (SPZ) administered with antimalarial drugs (PfSPZ-CVac), confers superior sterilizing protection against infection when compared to vaccination with replication-deficient, radiation-attenuated PfSPZ. However, the requirement...
4.
Goswami D, Kumar S, Betz W, Armstrong J, Haile M, Camargo N, et al.
iScience
. 2022 May;
25(5):104224.
PMID: 35521513
sporozoites invade hepatocytes and transform into liver stages within a parasitophorous vacuole (PV). The parasites then grow and replicate their genome to form exoerythrocytic merozoites that infect red blood cells....
5.
Goswami D, Betz W, Locham N, Parthiban C, Brager C, Schafer C, et al.
JCI Insight
. 2020 Jun;
5(13).
PMID: 32484795
Whole-sporozoite vaccines engender sterilizing immunity against malaria in animal models and importantly, in humans. Gene editing allows for the removal of specific parasite genes, enabling generation of genetically attenuated parasite...
6.
Vu K, Adler H, Gibbons E, Pearson J, Betz W
IDCases
. 2019 Aug;
18:e00599.
PMID: 31453102
Central nervous system (CNS) involvement occurs in about 1% of all tuberculosis (TB) cases, classically presenting as a meningitis. Intracerebral tuberculomas are a much rarer manifestation. We describe the case...
7.
Arredondo S, Swearingen K, Martinson T, Steel R, Dankwa D, Harupa A, et al.
Front Cell Infect Microbiol
. 2018 Dec;
8:413.
PMID: 30547015
Within the liver, sporozoites traverse cells searching for a "suitable" hepatocyte, invading these cells through a process that results in the formation of a parasitophorous vacuole (PV), within which the...
8.
Cardarelli R, Elder W, Weatherford S, Roper K, King D, Workman C, et al.
J Interprof Care
. 2018 Mar;
32(5):556-565.
PMID: 29601219
Chronic pain is increasingly recognized as a public health problem. We assessed the effectiveness of a multi-modal, interprofessional educational approach aimed at empowering healthcare professionals to make deliberative changes, especially...
9.
Flannery E, Foquet L, Chuenchob V, Fishbaugher M, Billman Z, Navarro M, et al.
JCI Insight
. 2018 Jan;
3(1).
PMID: 29321371
Malaria eradication necessitates new tools to fight the evolving and complex Plasmodium pathogens. These tools include prophylactic drugs that eliminate Plasmodium liver stages and consequently prevent clinical disease, decrease transmission,...