Debashree Goswami
Overview
Explore the profile of Debashree Goswami including associated specialties, affiliations and a list of published articles.
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Articles
14
Citations
126
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0
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Recent Articles
1.
Zanghi G, Patel H, Smith J, Camargo N, Bae Y, Hesping E, et al.
Nat Microbiol
. 2025 Jan;
10(2):569-584.
PMID: 39891010
Gene expression of Plasmodium falciparum (Pf) liver-stage (LS) parasites has remained poorly characterized, although they are major vaccine and drug targets. Using a human liver-chimaeric mouse model and a fluorescent...
2.
3.
Goswami D, Arredondo S, Betz W, Armstrong J, Kumar S, Zanghi G, et al.
Commun Biol
. 2024 Oct;
7(1):1387.
PMID: 39455824
Malaria, caused by Plasmodium parasites, imposes a significant health burden and live-attenuated parasites are being pursued as vaccines. Here, we report on the creation of a genetically attenuated parasite by...
4.
Goswami D, Patel H, Betz W, Armstrong J, Camargo N, Patil A, et al.
EMBO Mol Med
. 2024 Mar;
16(4):723-754.
PMID: 38514791
Vaccination with infectious Plasmodium falciparum (Pf) sporozoites (SPZ) administered with antimalarial drugs (PfSPZ-CVac), confers superior sterilizing protection against infection when compared to vaccination with replication-deficient, radiation-attenuated PfSPZ. However, the requirement...
5.
Patel H, Minkah N, Kumar S, Zanghi G, Schepis A, Goswami D, et al.
Nat Commun
. 2024 Mar;
15(1):2104.
PMID: 38453916
Malaria-causing Plasmodium parasites first replicate as liver stages (LS), which then seed symptomatic blood stage (BS) infection. Emerging evidence suggests that these stages impact each other via perturbation of host...
6.
Goswami D, Kumar S, Betz W, Armstrong J, Haile M, Camargo N, et al.
iScience
. 2022 May;
25(5):104224.
PMID: 35521513
sporozoites invade hepatocytes and transform into liver stages within a parasitophorous vacuole (PV). The parasites then grow and replicate their genome to form exoerythrocytic merozoites that infect red blood cells....
7.
Goswami D, Minkah N, Kappe S
J Hepatol
. 2021 Oct;
76(3):735-737.
PMID: 34711453
No abstract available.
8.
Steel R, Vigdorovich V, Dambrauskas N, Wilder B, Arredondo S, Goswami D, et al.
Sci Rep
. 2021 Jun;
11(1):11328.
PMID: 34059712
Following their inoculation by the bite of an infected Anopheles mosquito, the malaria parasite sporozoite forms travel from the bite site in the skin into the bloodstream, which transports them...
9.
Schafer C, Roobsoong W, Kangwanrangsan N, Bardelli M, Rawlinson T, Dambrauskas N, et al.
iScience
. 2020 Aug;
23(8):101381.
PMID: 32739836
The human malaria parasite Plasmodium vivax remains vastly understudied, mainly due to the lack of suitable laboratory models. Here, we report a humanized mouse model to test interventions that block...
10.
Goswami D, Betz W, Locham N, Parthiban C, Brager C, Schafer C, et al.
JCI Insight
. 2020 Jun;
5(13).
PMID: 32484795
Whole-sporozoite vaccines engender sterilizing immunity against malaria in animal models and importantly, in humans. Gene editing allows for the removal of specific parasite genes, enabling generation of genetically attenuated parasite...